Academic CV
2012.01~to date Department of Nutrition, School of Public Health Professor
2009.01~2011.12 Department of Nutrition, School of Public Health Associate Professor
2006.01~2008.12 Department of Nutrition, School of Public Health Lectorate
2002.09~2006.06 Nutrition and Food Hygiene, School of Public Health PhD Student
1999.09~2002.06 Nutrition and Food Hygiene, School of Public Health Graduate Student
1994.09~1999.06 Department of Preventive Medicine, Anhui Medical University Undergraduate Student
Professor Xia has long been engaged in the research into prevention of atherosclerosis (AS) through nutritional and dietary approaches. Focused on the association between glucose and lipid metabolic disorder and the underlying molecular mechanisms, the main research highlights are as follows: (1) The protective effects of anthocyanin on atherogenesis, the underlying mechanisms through which anthocyanin regulates cholesterol transportation, suppresses lipid synthesis and ameliorates insulin resistance and oxidative stress, as well as the protective effects of anthocyanin intervention on AS risks in patients with hypercholesterolemia and type 2 diabetes.; (2) The association between retinol binding protein 4 (RBP4) and the progression of AS, and the underlying mechanism through which RBP4 modulates hepatic lipid synthesis. Association between retinoid acid and NAFLD and its protective role in AS progression.
Social Appointments：
1. Committee member of Guangdong Nutrition Society（2013-2017年）
2. Deputy director of Nutrition Education and Health Promotion Committee of Guangdong Nutrition Society（2013-2017年）
3. Committee member of Basic Nutrition of China Nutrition Society（2013-2017年）
4. Committee member of Nutrition and Chronic disease control and prevention of China Nutrition Society（2013-2018年）
5. Committee member of the Youth Committee of Chinese Committee of Atherosclerosis（2012-2016年）
6. Member of American Nutrition Society
7. Member of American Chemical Society
8. Evaluation expert of National Academy of Science
9. Evaluation expert of Science and Technology Award of the Ministry of Education and Guangdong Province
10. Editorial board member: Journal of Liver and Clinical Research
11. Journal reviewers：BBA–Molecular and Cell Biology of Lipids、International Journal of Biochemistry & Cell Biology、The Journal of Nutrition, Health and Aging、Apoptosis、Plos One、Biochimie、Experimental Biology and Medicine、Lipids in Health and Disease
Major Projects
1、Ph.D. Program Foundation of Ministry of Education of China，20130171110058、Role of anthocyanin in the amelioration of mitochondrial functions and prevention against diabetes-induced endothelial injury. 2014/01–2016/12、Ongoing, Director.
2、National Natural Science Foundation of Guangdong Province，S2012020011104、Role of anthocyanin in the protection against diabetes and its complications and the underlying mechanism. 2012/11–2015/10、Ongoing, Director.
3、National Natural Science Foundation of China，81172663、Role of anthocyanin in endothelial oxidized cholesterol efflux and endothelial dysfunction. 2012/01-2015/12、Ongoing, Director.
4、Science and Technology Program of Guangzhou，Research into the prevention and control of metabolic syndrome through dietary and nutritional approaches. 2015/01–2016/12、Ongoing, Director.
5、National Natural Science Foundation of China，81072301、Role of anthocyanin in endothelial progenitor cell activation and the underlying mechanism for the repairmen of endothelial injury induced by diabetes. 2011/01–2013/12、Accomplished, Director.
6、New-century Training Program Foundation for the Talents by the State Education Commission，NCET-10-0813、Role of AMPK signaling pathway in the amelioration of high glucose-induced endothelial dysfunction. 2010/01–2012/12、Accomplished, Director.
Representative Publications
1. Zhou WJ, Lin JW, Chen HE, Wang JJ, Liu Y, Xia M*. Retinoic acid induces macrophage cholesterol efflux and inhibits the atherosclerotic plaque formation in apolipoprotein E-deficient mice. Br J Nutr.（accepted）（*Corresponding author, IF=3.342）
2. Liu Y, Chen H, Wang J, Zhou W, Sun R, Xia M*. Association of serum retinoic acid with hepatic steatosis and liver injury in nonalcoholic fatty liver disease. Am J Clin Nutr. 2015: ajcn105155. （*Corresponding author, IF=6.918）
3. Wang J, Chen H, Liu Y, Zhou W, Sun R, Xia M*. Retinol binding protein 4 induces mitochondrial dysfunction and vascular oxidative damage. Atherosclerosis. 2015; 240(2): 335-344. （*Corresponding author, IF=3.971）
4. Liu Y, Chen H, Wang J, Zhou W, Sun R, Xia M*. Elevated retinol binding protein 4 induces apolipoprotein B production and associates with hypertriglyceridemia. J Clin Endocrinol Metab. 2015; 100(5):E720-E728. （*Corresponding author, IF=6.31）
5. Li D, Zhang Y, Liu Y, Sun R, Xia M*. Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity and prevents insulin resistance in diabetic patients. J Nutr. April 2015 jn.114.205674（*Corresponding author，IF=4.227）
6. Liu Y, Wang D, Chen H, Xia M*. Circulating retinol binding protein 4 is associated with coronary lesion severity of patients with coronary artery disease. Atherosclerosis. 2015;238: 45–51.（*Corresponding author，IF=3.971）
7. Fu X, Huang X, Li P, Chen W, Xia M*. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144. Free Radic Biol Med. 2014; 71:1-15.（*Corresponding author，IF=5.71）
8. Sun RF, Wang XM, Liu Y, Xia M*. Dietary supplementation with fish oil alters expression levels of proteins governing mitochondrial dynamics and prevents high-fat diet-induced endothelial dysfunction. Br J Nutr. 2014;112(2):145–153. （*Corresponding author，IF=3.342）
9. Liu Y, Li D, Zhang YH, Sun RF, Xia M*. Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Am J Physiol Endocrinol Metab. 2014;306(8):E975–E988.（*Corresponding author，IF=4.088）
10. Liu Y, Wang D, Li D, Sun RF, Xia M*. Associations of retinol binding protein 4 with oxidative stress, inflammatory markers, and the metabolic syndrome in middle-aged and elderly Chinese population. Diabetol Metab Syndr. 2014;6(1): 25.（*Corresponding author，IF=2.50）
11. Zhu Y, Huang X, Zhang Y, Wang Y, Liu Y, Sun R, Xia M*. Anthocyanin supplementation improves HDL-associated paraoxonase 1 activity and enhances cholesterol efflux capacity in subjects with hypercholesterolemia. J Clin Endocrinol Metab. 2014;99(2):561–569.（*Corresponding author，IF=6.31）
12. Guo H*, Zhong R, Liu Y, Jiang X, Tang X, Li Z, Xia M*, Ling W. Effects of bayberry juice on inflammatory and apoptotic markers in young adults with features of non-alcoholic fatty liver disease. Nutrition. 2014;30(1):198–203.（*Co-Corresponding author，IF=3.046）
13. Xia M* , Liu Y, Guo H, Wang D, Wang Y, Ling W*. Retinol binding protein 4 stimulates hepatic SREBP-1 and increases lipogenesis through PGC-1beta- dependent pathway. Hepatology. 2013;58(2):564–575.（*Co-Corresponding author，IF=11.19）
14. Zhang Y, Wang X, Wang Y, Liu Y, Xia M*. Supplementation of cyanidin-3-O –β-glucoside promotes endothelial repair and prevents enhanced atherogenesis in diabetic apolipoprotein E-deficient mice. J Nutr. 2013;143(8):1248–1253.（*Corresponding author，IF=4.227）
15. Wang M, Wang D, Zhang YH, Wang XM, Liu Y, Xia M*. Adiponectin increases macrophages cholesterol efflux and suppresses foam cell formation in patients with type 2 diabetes mellitus. Atherosclerosis. 2013;229(1):62–70. （*Corresponding author，IF=3.971）
16. Zhu W, Jia Q, Wang Y, Zhang Y, Xia M*. The anthocyanin cyanidin-3-O-β- glucoside, a flavonoid, increases hepatic glutathione synthesis and protects hepatocytes against reactive oxygen species during hyperglycemia: Involvement of a cAMP-PKA-dependent signaling pathway. Free Radic Biol Med. 2012;52(2): 314–327.（*Corresponding author，IF=5.71）
17. Wang Y, Zhang Y, Wang X, Liu Y, Xia M*. Supplementation with cyanidin-3-O -β-glucoside protects against hypercholesterolemia-mediated endothelial dysfunction and attenuates atherosclerosis in apolipoprotein E-deficient mice. J Nutr. 2012; 142(6):1033–1037.（*Corresponding author，IF=4.227）
18. Guo H, Xia M*, Zou T, Ling W*, Zhong R, Zhang W. Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1. J Nutr Biochem. 2012;23(4):349–360.（*Co-Corresponding author，IF=4.592）
19. Wang Y, Zhang Y, Wang X, Liu Y, Xia M*. Cyanidin-3-O-β-glucoside induces oxysterol efflux from endothelial cells: role of liver X receptor alpha. Atherosclerosis. 2012;223(2): 299–305.（*Corresponding author，IF=3.971）
20. Guo H, Li D, Ling W, Feng X, Xia M*. Anthocyanin inhibits high glucose- induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ. J Lipid Res. 2011; 52(5):908–922.（*Corresponding author，IF=4.73）
21. Zhang Y, Qiu J, Wang X, Zhang Y, Xia M*. AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300. Arterioscler Thromb Vasc Biol. 2011;31(12): 2897–2908.（*Corresponding author，IF=5.553）
22. Wang Y, Wu Z, Li D, Wang D, Wang X, Feng X, Xia M*. Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress. J Biol Chem. 2011; 286(13):11119–11131.（*Corresponding author，IF=4.6）
23. Li D, Zhang Y, Ma J, Ling W*, Xia M*. Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia-induced endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2010;30(7):1354–1362.（*Co-Corresponding author，IF=5.553）
24. Xia M*, Li G, Ma J, Ling W*. Phosphoinositide 3-kinase mediates CD40 ligand-induced oxidative stress and endothelial dysfunction via Rac1 and NADPH oxidase 2. J Thromb Haemost. 2010;8(2):397–406.（*Co-Corresponding author，IF=5.55）
25. Li D, Wang D, Wang Y, Ling W, Feng X, Xia M*. Adenosine monophosphate- activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem. 2010;285(43):33499–33509.（*Corresponding author，IF=4.6）
Student Cultivation
Graduated Ph.D student: 1，Graduated Master student: 8，Ph.D student: 3，Master student: 7
Honors and Awards
1. “Talent Training Program” for institutions of higher education of Guangdong Province（2014）
2. The Fok Ying-Tong Education Foundation for young teachers（2012）
3. Dingying Technology Award of Guangdong Province（2011）
4. “Talent Training Program” for institutions of higher education of Guangdong Province（2010）
5. The First Prize of Science and Technology of Guangdong Province（2010）
6. The First Prize of Natural Science of the Ministry of Education（2010）
7. Excellent Talents in the new century of the Ministry of Education（2009）
8. National Outstanding doctor’s degree thesis（2008）
9. Influential cardiovascular thesis in China (2006-2007)
