bbin平台

Professor, Faculty of Preventive Medicine, Associate Dean of School of Public Health, Sun Yat-sen University.

Professor Chen received her MD degree from Guangzhou Medical College, China in 1987 and her MS and PhD degrees from the Sun Yat-sen University of Medical Sciences, respectively in 1994 and 2001. Upon graduation from Guangzhou Medical College, she started an academic career at the Institute of Chemical Carcinogenesis of Guangzhou Medical College. In 1993-1995, she worked at National Center for Toxicological Research (NCTR), USA as a visiting scholar. In 2001-2004, she received her postdoctoral training at Dana Farber Cancer Institute, Harvard Medical School, USA. Since joining the Sun Yat-sen University in 2005, Professor Chen has served as Professor and the academic leader of Department of Toxicology, and the Associate Dean of the School of Public Health.

Since 2005, Professor Chen has received numerous prestigious awards including a Distinguished Young Scholar and two Key program of National Natural Science Foundation of China (NSFC), a Program for New Century Excellent Talents in University (Ministry of Education), a National Key Basic Research and Development Program, a National High Technology Research and Development Key Program of China, a Commonweal Program of Ministry of Health of China, and a Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (GDUPS). As an associated editor, she had 4 books and more than 100 journal papers published, as well as more than 1500 citations on publications. 

Professor Chen also served as the board member of the council of Chinese society of Toxicology and Environmental Mutagen Society; the chairman of the council of Guangdong Environmental Mutagen Society; a Guangzhou Municipal People's Government Emergency Management Specialist. Currently, She is an editorial board member of Toxicology Research (RSC Publishing).

Research

Professor Chen’s research areas include the application of human cell transformation model in potent carcinogen screening, epigenetic mechanism of chemical carcinogenesis, monitoring of environmental and occupational exposure, and identification of biomarkers for risk assessment.

Grant Awards

1.    The Mechanism of Hematoxicity and Mode of Action under Low-dose Occupational Benzene Exposure. Key Grant of National Natural Science Fund. (2015-2019, 814300795) (PI)
2.    The Epigenetic Regulation of Gene Expression of Metabolic Enzymes. Natural Science Foundation of Guangdong Province (S2012040007713) (PI)
3.    The Evaluation of Early Adverse Health Effects of Occupational Exposure. National "Twelfth Five-Year" Plan for Science & Technology (2014BAI12B02) (co-PI)
4.    The Evaluation of Chemical Carcinogenicity Using Toxicity Pathway Approach. Supported by Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme GDUPS (2010) (PI) 
5.    The Development of Technology for Occupational Health Inspection And Surveillance. Supported by Ministry of Health of China (2009-2013, 200902006) (co-PI)
6.    Network Regulation of Non-coding RNA in Human Cancer. Supported by a National Key Basic Research and Development Program (2010-2014, 2010CB912803) (co-PI)
7.    The Development of Key Technology in Risk Assessment of Environmental Hazards. Supported by the National High Technology Research and Development Key Program of China (2008-2011, 2008AA062504) (co-PI)
8.    Interaction Among Epigenetic Regulatory Network. Supported by National Natural Science Funds for Distinguished Young Scholar.（2010-2013, 30925029）(PI)
9.    Epigenetic Alterations During Environmental Carcinogen-induced Cell Transformation. Supported by the Key Grant of National Natural Science Fund. (2007-2010, 30630055) (PI)
10.    Protein Phosphatase 2A and Cell Transformation. Supported by Program for New Century Excellent Talents in University. (2005-2007, NCET-05-0722)  (PI)
11.    In Vitro System for Metabolic Activation. Supported by Research Fund for the Doctoral Program of Higher Education of China. (2006-2007, 20060558024)  (PI)
12.    Establishment and Application of Human Cell Models. Supported by National Natural Science Fund. (2006-2008, 30571588) (PI)
13.    Technology in Occupational Health Surveillance and Health Improvement. Supported by Ministry of Health of China. (2010-2013, 200902006) (co-PI)
14.    Functional Networks and Regulatory Mechanism of miRNA in Cancer. Supported by National Key Basic Research and Development Program (973 project). (2010-2014, 2010CB912800) (co-PI)
15.    Risk Assessment of Environmental Pollution and Key Control Technology. Supported by National High Technology Research and Development Key Program of China. (2008-2011, 2008AA062504) (co-PI)
16.    Biomarkers and Environmental Pollution. Supported by National Key Basic Research and Development Program. (2002-2006, 2002CB512903) (co-PI)
17.    The Detection of Sperm Chromosomal Aberration in Workers Exposed to Benzene and Carbon Disulfide Using Multi-fluorescene in Situ Hybridization. Supported by Guangdong Provincial Natural Science Fund. (2001-2003, 001334) (co-PI)
18.    The Establishment of Mouse Model with Telomerase Gene Knocked out. Supported by Guangdong Provincial Natural Science Fund (2001-2003, 001374) (PI)
19.    Low Level Lead Exposure And Neurotrophins. Supported by Fund of School of Public Health, SUMS. (1998-2000, 2944) (PI)
20.    The Anti-tumor Effect of Telomerase hTR Antisense Oligonucleotides. Supported by Fund of Sun    Yat-sen University of Medical Sciences (SUMS). (1998-1999, 100267) (PI)
21.    The Expression of Telomerase Activity during Rat Colon Carcinogenesis and The applications of Telomerase Inhibitors on Cancer Therapy. Supported by National Natural Science Fund. (1997-1999, 39670644) (co-PI)

Selected Publication

1.    Zhini He, Huawei Duan, Biao Zhang, Miao Li, Liping Chen, Bo Zhang, Xiaonian Zhu, Chen Gao, Jie Li, Xiao Zhang, Jingmaio Zhang, Shan Wang, Xiaowen Zeng, Daochuan Li, Xiumei Xing, Zhengbao Zhang, Lu Ma, Qing Bai, Caixia Liu, Yongmei Xiao, Yuxin Zheng, and Wen Chen*. CpG Site-specific RASSF1a Hypermethylation Is Associated with Occupational PAHs Exposure And Genomic Instability. Toxicol Res. 2015; 4, 848-57.
2.    Liu CX, XM Xing, LP Chen, DC Li, XW Zeng, Q Wei, C Gao, ZB Zhang, JM Zhang, ZN He, L Ma, J Li, HW Duan, Q Wang, YX Zheng, YM Xiao *, and W Chen*. Specific Histone Modifications Regulates The Expression of Aryl Hydrocarbon Receptor in 16HBE Cells Exposed to Benzo(a)pyrene. Toxicol Res. 2015;4(1):143-151  
3.    Zhu XN, Chen LP, Bai Q, Ma L, Li DC, Zhang JM, Gao C, Lei, ZN Zhang ZB, Xing XM, Liu CX, He ZN, Li J, Xiao YM, Zhang AH, Zeng XW * and W Chen*. PP2A-AMPK-HSF1 Axis Regulates Metal-inducible expression of HSPs And ROS Clearance. Cell Signaling. 2014; 26:825-832.
4.    Chen LP, Ma L, Bai Q, Zhu XN, Zhang JM, Wei Q, Li DC, Gao C, Zhang ZB, CX Liu, ZN He, XW Zeng, AH Zhang, WD Qu, Zhuang ZX, Wen Chen*, and YM Xiao*. Heavy Metal-Induced Metallothionein Expression Is Regulated by Specific Protein Phosphatase 2A Complexes. J Biol Chem. 2014; 289(32):22413-26.
5.    Li DC, Liu CX, Yu HH, Zeng XW, Xing XM, Chen LP, Gao C, Zhang ZB, Xiao YM, Duan HW, Zheng YX, Q Wang,* Wen Chen. AhR Is Negatively Regulated by miR-203 in Response to TCDD or BaPTreatment. Toxicol Res. 2014,3:142 
6.    Kalev P, Simicek M, Vazquez I, Munck S, Chen L, Soin T, Danda N, Chen W, Sablina A*. Loss of PPP2R2A Inhibits Homologous Recombination DNA Repair and Predicts Tumor Sensitivity to PARP Inhibition. Cancer Res. 2012;72(24):6414-24.
7.    P Yang, JX Ma, B Zhang, HW Duan, ZN He, JL Zeng, XW Zeng, DC Li, Q Wang, YM Xiao, CX Liu, Q Xiao, LP Chen, XN Zhu, XM Xing, ZF Li, SX Zhang, ZB Zhang, L Ma, EM Wang, ZX Zhuang, YX Zheng*, Wen Chen*. CpG Site-Specific Hypermethylation of p16INK4 In Peripheral Blood Lymphocytes of PAH-Exposed Workers. Cancer Epidem Biomar 2012; 21(1):182-90. 
8.    DC Li, Q Wang, CX Liu, HW Duan, XW Zeng, B Zhang, XD Li, J Zhao, SF Tang, ZF Li, XM Xing, P Yang, LP Chen, JL Zeng, XN Zhu, SX Zhang, ZB Zhang, L Ma, ZN He, EM Wang, YM Xiao, YX Zheng, W Chen*. Aberrant Expression of miR-638 Contributes to Benzo(a)pyrene–induced Human Cell Transformation. Toxicol Sci. 2012; 125(2): 382-391. 
9.    L-P Chen, Y-D Lai, D-C Li, X-N Zhu, P Yang, W-X Li, W Zhu, J Zhao, X-D Li, Y-M Xiao, Y Zhang, X-M Xing, Q Wang, B Zhang, Y-C Lin, J-L Zeng, S-X Zhang, C-X Liu, Z-F Li, X-W Zeng, Z-N Lin, Z-X Zhuang, and W Chen*. 4 Is Highly Expressed In Carcinogen-transformed Human Cells And Primary Human Cancers. Oncogene 2011; 30(26):2943-2953. 
10.    Q Wang, D-C Li, Z-F Li, C-X Liu, Y-M Xiao, B Zhang, X-D Li, J Zhao, L-P Chen, X-M Xing, S-F Tang, Y-C Lin, Y-D Lai, P Yang, J-L Zeng, Q Xiao, X-W Zeng, Z-N Lin, Z-X Zhuang and W Chen*. Upregulation of miR-27a Contributes to the Malignant Transformation of Human Bronchial Epithelial Cells Induced by SV40 Small T Antigen. Oncogene 2011; 30(36):3875-86. 
11.    Pang YQ, Ma RL, Li WX, Wang Q, Li DC, Xiao YM, Wei Q, Lin YC, Lai YD, Yang P, Tang S, Zhuang ZX, Zheng YX, Chen W*. Development of Human Cell Models for Assessing the Carcinogenic Potential of Chemicals. Toxicol Appl Pharm, 2008, 232:478-486.
12.    Sablina AA, Chen W (co-first author), Arroyo JD, Laura Corral, Melissa Hector, Sara E. Bulmer James A. DeCaprio, and Hahn WC. The Tumor Suppressor PP2A A Regulates The RalA GTPase. Cell, 2007; 129:969. 
13.    Chen W, Arroyo JD, Timmons JC, Possemato R, and Hahn WC. Cancer-associated PP2A A Subunit Mutations Contribute to Human Cell Transformation. Cancer Res, 2005;65(18):8183.
14.    Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, and Hahn WC. Identification of Specific PP2A Complexes Involved in Human Cell Transformation. Cancer Cell, 2004; 5(2):127-136
15.    Chen W, Hahn WC. SV40 Early Region Oncoproteins and Human Cell Transformation. Histol  Histopath, 2003; 18:541.
16.    Chen W, Zhou YG, Nichols J, Chung KT, Hart RW, Chou MW. Effect of Dietary Restriction on Benzo[a]pyrene Metabolic Activation and Pulmonary BaP-DNA Adduct Formation in Mouse. Drug Chem Toxicol, 1996; 19(1&2):21.
17.    Chen W, Nichols J, Zhou YG, Chung KT, Hart RW, Chou MW. Effect of Dietary Restriction on Glutathione S-transferase Activity Specific Toward Aflatoxin B1-8,9-epoxide. Toxicology Lett, 1995; 78:235.

Contact information 
Department of Toxicology, Faculty of Preventive Medicine, School of Public Health, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou, 510080, China
Tel: 020-87330599;  Fax: 020-87330446;  Email: [email protected]