【职 称】 副教授（博士生导师）
【所属部门】 卫生毒理学系
【电子邮件】 [email protected]
【研究方向】分子毒理学
【研究生招生专业】卫生毒理学、公共卫生硕士（MPH）
【学术简历】
bbin平台-bbin官网-bbin电子 副教授/博士生导师，入选国家高层次人才计划，卫生毒理学系副主任。研究方向为化学致癌的表观遗传调控机制和环境化学物致癌性风险评估。主持国家自然科学基金3项，广东省自然科学基金3项，高等学校博士学科点专项科研基金1项，作为骨干参与国家自然科学基金重点项目，国家重点研发计划和广东省自然科学基金研究团队项目。授权发明专利3项。共发表SCI论著90多篇，包括Environ Health Perspect，Journal of Hazardous Materials，Particle and Fibre Toxicology，Archives of Toxicology，Oncogene，Toxicological Sciences，Environmental pollution，Biochemical Pharmacology，Journal of Biological Chemistry等权威期刊。现任中国毒理学会生化与分子毒理学专业委员会秘书长、中国诱变剂学会致突变专业委员会青年委员会副主任委员等职务。担任Toxicol Appl Pharmacol，《癌变·畸变·突变》等国际国内杂志编委。
【教育及工作经历】
2019/02-至今 中山大学 bbin平台
副教授/博导
2016/04-2019/01 中山大学 bbin平台
研究员
2014/03-2016/03 美国马里兰大学 药学院 博士后
2011/09-2014/02 中山大学 bbin平台
讲师
2006/09-2011/07 中山大学 卫生毒理学 博士
2001/09-2006/07 济宁医学院 预防医学系 学士
【社会兼职】
中国毒理学会生化与分子毒理专委会秘书长
中国诱变剂学会致突变专业委员会青年委员会副主任委员
中国诱变剂学会生物标志物专委会委员
中华预防医学会食品卫生分会委员
《癌变·畸变·突变》杂志编委
【承担课题】
1. 基于人源3D类器官模型的重稀土毒性测试和职业健康风险预警研究 国家自然科学基金专项项目（主持人 2023-2025）
2. 可调控的特定基因甲基化修饰与功能研究细胞模型的建立与应用 国家自然科学基金面上项目（主持人 2019-2022）
3. TRIM36基因高甲基化在多环芳烃诱导肺癌发生过程中的作用及机制研究 国家自然科学基金青年项目（主持人 2017-2019）
4.基于体外消化系统和3D共培养细胞模型建立经口暴露重金属毒性评价体系 广东省自然科学基金面上项目（主持人 2021-2023）
5. 臭氧暴露对机体损伤的表观遗传时钟和毒性通路扰动的分子机制 国家自然科学基金重点项目（参与人 2022-2026）
6. 食品中典型持久性有机污染物健康危害与毒性机制 国家重点研发计划项目（骨干 2018-2021）
7. 交通源超细颗粒物暴露与神经退行性疾病风险评估的关键技术及应用 国家重点研发计划项目（骨干 2019-2022）
8. 基于AOP框架构建大气细颗粒物暴露致肺癌的风险评估模式 广东省自然科学基金团队项目 （骨干2018-2023）
【代表性论文】（#第一作者，*通讯作者）
1. Rui Zhang, Shen Chen, Ziwei Wang, Lizhu Ye, Yue Jiang, Miao Li, Xinhang Jiang, Hui Peng, Zhanyu Guo, Liping Chen, Rong Zhang, Yujie Niu, Michael Aschner, Daochuan Li(*), Wen Chen(*).Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Subchronically Exposed to Ambient Particulate Matter. Environ Health Perspect. 2023 Jul;131(7):77006.
2. Shuangjian Qin, Huixian Zeng, Qizhen Wu, Qingqing Li, Mohammed Zeeshan, Lizhu Ye, Yue Jiang, Rui Zhang, Xinhang Jiang, Miao Li, Rong Zhang, Wen Chen, Wei-Chun Chou, Guang-Hui Dong, Dao-Chuan Li(*), Xiao-Wen Zeng(*). An integrative analysis of lipidomics and transcriptomics in various mouse brain regions in response to real-ambient PM2.5 exposure. Sci Total Environ. 2023 Oct 15:895:165112.
3. Chi Xu, Shuyun Jiang, Xingyu Ma, Zeyong Jiang, Youguang Pan,Xiang Li, Liying Zhang, Hao Zhou, Shen Chen, Xiumei Xing, Liping Chen, Wenfan Fu, Qing Wang, Wen Chen, Daochuan Li(*). CRISPR-based DNA methylation editing of NNT rescues the cisplatin resistance of lung cancer cells by reducing autophagy. Arch Toxicol. 2023 Feb;97(2):441-456.
4. Hongxu Bao, Benying Li, Qing You, Xinyu Dun, Zhen Zhang, Yanan Liang, Yahui Li, Qixiao Jiang, Rong Zhang, Rui Chen, Wen Chen, Yuxin Zheng, Daochuan Li(*), Lianhua Cui*. Exposure to real-ambient particulate matter induced vascular hypertrophy through activation of PDGFRβ. J Hazard Mater. 2023 Feb 11;449:130985.
5. Rui Zhang, Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Hui Peng, Zhanyu Guo, Miao Li, Xinhang Jiang, Ping Guo, Dianke Yu, Rong Zhang, Yujie Niu, Yuan Zhuang, Michael Aschner, Yuxin Zheng, Daochuan Li(*), Wen Chen*. Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure. Part Fibre Toxicol. 2022 Jun 23;19(1):42.
6. Shen Chen(#), Daochuan Li(#), Dianke Yu, Miao Li, Lizhu Ye, Yue Jiang, Shijie Tang, Rui Zhang, Chi Xu, Shuyun Jiang, Ziwei Wang, Michael Aschner, Yuxin Zheng, Liping Chen, Wen Chen. Determination of tipping point in course of PM2.5 organic extracts-induced malignant transformation by dynamic network biomarkers. J Hazard Mater. 2022 Mar 15;426:128089.
7. Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Qiong Li, Haiyan Zhang, Rui Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yujie Niu, Qun Zhao, Jianhui Liu, Gangfeng Ouyang, Michael Aschner, Yuxin Zheng, Lihua Zhang, Wen Chen*, Daochuan Li(*). PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury. J Hazard Mater. 2022 Feb 15;424(Pt C):127624.
8. Zhengbao Zhang, Xiang Li, Shuyun Jiang, Chunfang Qiu, Ping Guo, Ziwei Wang, Chi Xu, Liying Zhang, Xingyu Ma, Shen Chen, Xiumei Xing, Liping Chen, Qing Wang, Huimin Ma, Xiaowen Zeng, Wen Chen, Daochuan Li(*). Assessing the neurotoxicity of airborne nano-scale particulate matter in human iPSC-derived neurons using a transcriptomics benchmark dose model. Toxicol Appl Pharmacol. 2022 Aug 15;449:116109.
9. Zhengbao Zhang(#), Xiumei Xing(#), Shuyun Jiang, Chunfang Qiu, Ziying Mo, Shen Chen, Liping Chen, Qing Wang, Yongmei Xiao, Guanghui Dong, Yuxin Zheng, Wen Chen, Daochuan Li(*). Global H3K79 di-methylation mediates DNA damage response to PAH exposure in Chinese coke oven workers. Environ Pollut. 2021;268(Pt B):115956.
10. Xiumei Xing(#), Zhini He(#), Ziwei Wang, Ziying Mo, Liping Chen, Boyi Yang, Zhengbao Zhang, Shen Chen, Lizhu Ye, Rui Zhang, Yuxin Zheng, Wen Chen, Daochuan Li(*). Association between H3K36me3 modification and methylation of LINE-1 and MGMT in peripheral blood lymphocytes of PAH-exposed workers. Toxicol Res (Camb). 2020;9(5):661-668.
11. Daochuan Li, Shen Chen, Qiong Li, Liping Chen, Haiyan Zhang , Huiyao Li , Dianke Yu, Rong Zhang, Yujie Niu, Shaoyou Lu, Lizhu Ye, Xiaowen Zeng, Guanghui Dong, Rui Chen, Michael Aschner, Yuxin Zheng, Wen Chen(*). Caloric restriction attenuates C57BL/6 J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure. Part Fibre Toxicol. 2020; 17(1):22.
12. Shen Chen(#), Daochuan Li(#), Xiaonen Wu(#), Liping Chen, Bin Zhang, Yafei Tan, Dianke Yu, Yong Niu, Huawei Duan, Qiong Li, Rui Chen, Michael Aschner, Yuxin Zheng, Wen Chen(*). Application of cell-based biological bioassays for health risk assessment of PM2.5 exposure in three megacities, China. Environ Int. 2020; 139:105703.
13. Shen Chen(#), Daochuan Li(#), Haiyan Zhang(#), Dianke Yu, Rui Chen, Bin Zhang, Yafei Tan, Yong Niu, Huawei Duan, Bixian Mai, Shejun Chen, Jianzhen Yu, Tiangang Luan, Liping Chen, Xiumei Xing, Qiong Li, Yongmei Xiao, Guanghui Dong, Yujie Niu, Michael Aschner, Rong Zhang, Yuxin Zheng, Wen Chen(*). The development of a cell-based model for the assessment of carcinogenic potential upon long-term PM2.5 exposure. Environ Int. 2019; 131:104943.
14. Daochuan Li, Rong Zhang, Lianhua Cui, Chen Chu, Haiyan Zhang, Hao Sun, Jing Luo, Lixiao Zhou, Liping Chen, Jian Cui, Shen Chen, Bixian Mai, Shejun Chen, Jianzhen Yu, Zongwei Cai, Jianqing Zhang, Yousheng Jiang, Michael Aschner, Rui Chen, Yuxin Zheng, Wen Chen(*). Multiple organ injury in male C57BL/6J mice exposed to ambient particulate matter in a real-ambient PM exposure system in Shijiazhuang, China. Environ Pollut. 2019;248:874-887.
15. Liping Chen(#), Ping Guo(#), Haiyan Zhang, Wenxue Li, Chen Gao, Zhenlie Huang, Junling Fan, Yuling Zhang, Xue Li, Xiaoling Liu, Fangping Wang, Shan Wang, Qingye Li, Zhini He, Huiyao Li, Shen Chen, Xiaonen Wu, Lizhu Ye, Qiong Li, Huanwen Tang, Qing Wang, Guanghui Dong, Yongmei Xiao, Wen Chen, and Daochuan Li(*). Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of cytochrome P4502E1. J Biol Chem. 2019;294(7):2486-2499.
16. Jie Li(#), Xiumei Xing(#), Xinjie Zhang(#), Boxuan Liang, Zhini He, Chen Gao, Shan Wang, Fangping Wang, Haiyan Zhang, Shan Zeng, Junling Fan, Liping Chen, Zhengbao Zhang, Bo Zhang, Caixia Liu, Qing Wang, Weiwei Lin, Guanghui Dong, Huanwen Tang, Wen Chen, Yongmei Xiao, Daochuan Li(*). Enhanced H3K4me3 modifications are involved in the transactivation of DNA damage responsive genes in workers exposed to low-level benzene. Environ Pollut. 2018; 234:127-135.
17. Shan Wang(#), Liping Chen(#), Qing Wang, Zhini He, Shen Chen, Haiyan Zhang, Huiyao Li, Ping Guo, Qiong Li, Rui Zhang, Xiumei Xing, Xiaowen Zeng, Weiwei Lin, Yongmei Xiao, Guang-Hui Dong, Lu Ma, Namratha Gurram, Aihua Zhang, Wen Chen, Daochuan Li(*). Strain differences between CD-1 and C57BL/6 mice in expression of metabolic enzymes and DNA methylation modifications of the primary hepatocytes. Toxicology. 2019;412:19-28.
18. Chen Gao(#), Xiumei Xing(#), Zhini He, Shen Chen, Shan Wang, Qingye Li, Ping Guo, Haiyan Zhang, Huiyao Li, Liping Chen, Qing Wang, Jian Zhao, Yongmei Xiao, Wen Chen(*), Daochuan Li(*). Hypermethylation of PGCP gene is associated with human bronchial epithelial cells immortalization. Gene. 2018; 642:505-512.
19. Huiyao Li(#), Daochuan Li(#), Zhini He, Junling Fan, Qingye Li, Xiaoling Liu, Ping Guo, Haiyan Zhang, Shen Chen, Qiong Li, Rui Zhang, Xiumei Xing, Xiaowen Zeng, Aihua Zhang, Huanwen Tang, Guanghui Dong, Qing Wang, Yongmei Xiao, Liping Chen(*), Wen Chen(*). The Effects of Nrf2 Knockout on Regulation of Benzene-induced Mouse Hematotoxicity. Toxicol Appl Pharmacol. 2018; 358:56-67.
20. Zhini He(#), Daochuan Li(#), Junxiang Ma(#), Liping Chen, Huawei Duan, Bo Zhang, Chen Gao, Jie Li, Xiumei Xing, Jian Zhao, Shan Wang , Fangping Wang, Haiyan Zhang, Huiyao Li, Shen Chen, Xiaowen Zeng, Qing Wang, Yongmei Xiao, Yuxin Zheng, Wen Chen(*). TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation. Environ Pollut. 2017; 225:93-103.
21. Xiaonian Zhu(#), Daochuan Li(#), Zhengbao Zhang, Wei Zhu, Wenxue Li, Jian Zhao, Xiumei Xing, Zhini He, Shan Wang, Fangping Wang, Lu Ma, Qing Bai, Xiaowen Zeng, Jie Li, Yongmei Xiao, Qing Wang, Liping Chen, and Wen Chen. Persistent Phosphorylation at Specific H3 Serine Residues Involves in Chemical Carcinogen-induced Cell Transformation. Mol Carcinog. 2017; 56(5):1449-1460.
22. Daochuan Li, Bryan Mackowiak, Timothy G. Brayman, Michael Mitchell, Lei Zhang,Shiew-Mei Huang, Hongbing Wang(*). Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells. Biochem Pharmacol. 2015; 98(1):190-202.
23. Daochuan Li, Caixia Liu Haohui Yu, Xiaowen Zeng, Xiumei Xing, Liping Chen, Chen Gao, Zhengbao Zhang, Yongmei Xiao, Huawei Duan, Yuxin Zheng, Qing Wang, and Wen Chen. AhR Is Negatively Regulated by miR-203 in Response to TCDD or BaP Treatment. Toxicol Res. 2014; 3:142-151.
24. Daochuan Li, Qing Wang, Caixia Liu, Huawei Duan, Xiaowen Zeng, Bo Zhang, Xiaodong Li, Jian Zhao, Shifu Tang, Zhifang Li, Xiumei Xing, Ping Yang, Liping Chen, Junling Zeng, Xiaonian Zhu, Shixin Zhang, Zhengbao Zhang, Lu Ma, Zhini He, Erman Wang, Yongmei Xiao, Yuxin Zheng, Wen Chen. Aberrant Expression of miR-638 Contributes to Benzo(a)pyrene–induced Human Cell Transformation. Toxicol Sci. 2012; 125(2): 382-391.
25. Qing Wang(#), Daochuan Li(#), Zhifang Li, Caixia Liu, Yongmei Xiao, Bo Zhang, Xiaodong Li, Jian Zhao, Liping Chen, Xiumei Xing, Shifu Tang, Yucun Lin, Ping Yang, Junling Zeng, Qin Xiao, Xiaowen Zeng, Zhongning Lin, Zhixiong Zhuang, Shimei Zhuang, Wen Chen(*). Upregulation of miR-27a Contributes to the Malignant Transformation of Human Bronchial Epithelial Cells Induced by SV40 Small T Antigen. Oncogene. 2011; 30(36):3875-86.
26. Liping Chen(#), Yandong Lai(#), Daochuan Li(#), Xiaonian Zhu, Ping Yang, Wenxue Li, Wei Zhu, Jian Zhao, Xiaodong Li, Yongmei Xiao, Y Zhang, Xiumei Xing, Qing Wang, Bo Zhang, Yucun Lin, Junling Zeng, Shixin Zhang, Caixia Liu, Zhifang Li, Xiaowen Zeng, Zongning Lin, Zhixiong Zhuang, Wen Chen(*). α4 is highly expressed in carcinogen- transformed human cells and primary human cancers. Oncogene. 2011; 30(26):2943-53.
【参编著作】
1. 《现代毒理学》，人民卫生出版社，2018年
2. 《基于毒作用模式的典型食品污染物风险评估》，中山大学出版社，2021年
招生专业
卫生毒理学
