学术简历
[学术经历]
2002.09～2007.06 bbin平台-bbin官网-bbin电子
博士学位
1997.09～2002.06 中山医科大学bbin平台
学士学位
[工作经历]
2021.07~至今 中山大学bbin平台 副院长
2019.01~2021.07 中山大学教务部 副处长
2019.01~至今 bbin平台-bbin官网-bbin电子 卫生毒理系 副主任
2015.09~2018.12 预防医学系 党支部书记
2013.01~2015.01 美国斯坦福大学临床科研中心基因研究所 访问学者
2018.04~至今 bbin平台-bbin官网-bbin电子
卫生毒理系 教授
2011.01~2018.04 bbin平台-bbin官网-bbin电子
预防医学系 副教授
2007.07~2010.12 bbin平台-bbin官网-bbin电子
预防医学系 讲师
社会兼职
中国环境诱变剂学会-环境表观遗传学专业委员会 主任委员 2023-2027
广东省医师协会公共卫生医师分会 副主任委员 2023-2027
广东省毒理学学会 副主任委员 2024-2029
《中国公共卫生》杂志 第七届编辑委员会青年编委 2017-2021
《癌变.畸变.突变》杂志第七届编辑委员会编委 2017-2021
主持的科研项目：
国家自然科学基金面上项目，82373546，基于人源类器官模型的锂电池产业金属混合暴露肾脏毒性检测及职业健康风险评估研究 2024.01-2027.12
国家自然科学基金面上项目，82073583，基于单细胞测序技术探讨聚苯乙烯微塑料诱导肝脏脂质代谢异常的作用机制，2021.01-2024.12
国家重点研发计划， SQ2019YFC1604603，食品中重金属污染物去除技术及安全性评价，2019.12-2022.12
国家自然科学基金面上项目，81673140，长链非编码RNA在调控二甲基甲酰胺诱导肝脏毒性中的作用及其机制，2017.1-2020.12
国家自然科学基金面上项目，81273098，微小RNA在化学致癌物生物转化中的功能，2013.01-2016.12
国家自然科学青年基金项目，30800930，miRNA在化学致癌过程中的功能性研究，2009.01-2011.12
广东省自然科学基金面上项目，2024A1515012268，基于AOP网络和类器官模型开展重金属混合暴露肝毒性风险评估研究 2024.01-2026.12
广东省自然科学基金面上项目，2019A1515011457，miR-192-5p在二甲基甲酰胺诱导职业性肝损伤中的作用机制，2019.10-2022.09
近期发表的主要文章
- Lijie Xie, Xinchao Guan, Yixiang Zhou, Yujie He, Shilin Chen, Wanting Xiao, Jilong Yang, Jianyong Lu, Liecheng Hong, Qiansheng Hu, Qiong Wang, Chuanwen Li* and Qing Wang*. Exploring Associations and Mediating Factors between Multiple Trace Metals with Anemia in US Adults: Insight from NHANES 2017-2020. Nutrients. 2024. 16, 3424.
- Xue Zhang, Huan Gao, Xiaoyu Chen, Ziqi Liu, Han Wang, Mengxing Cui, Yajie Li, Yongjiang Yu, Shen Chen, Xiumei Xing, Liping Chen, Daochuan Li, Xiaowen Zeng, Qing Wang*. Identification of Sanguinarine as a novel antagonist for Perfluorooctanoate/Perfluorooctane Sulfonate-induced Senescence of Hepatocytes: An integrated computational and experimental analysis. Journal of Hazardous Materials. 2024. 478:135583
- Han Wang, Dongtian Miao, Yongjiang Yu, Zhihan Zhang, Youlong Zhu, Qing Wang*. PVA/PAA/DMTD electrospun nanofibrous membrane for the selective adsorption of Pb(II) ions in liquid foods. iScience. 2023, 108737.
- Peng H, Fu W, Chang C, Gao H, He Q, Liu Z, Cui M, Wang H, Yu Y, Wu Y, Zhang X, Jiang S, Xu C, Shen X, Zhang Z, Zhou Y, Li D*, Wang Q*. The transcription activity of OTX2 on p16 expression is significantly blocked by methylation of CpG shore in non-promoter of lung cancer cell lines. Transl Cancer Res. 2023;12(10):2582-2595.
- Zhai D, Zhou Y, Kuang X, Shao F, Zhen T, Lin Y, Wang Q*, Shao N*. Lnc NR2F1-AS1 Promotes Breast Cancer Metastasis by Targeting the MiR-25-3p/ZEB2 Axis. Int J Med Sci. 2023;20(9):1152-1162.
Mengxing Cui, Qianmei He, Ziwei Wang, Yongjiang Yu, Huan Gao, Ziqi Liu, Honghao Peng, Han Wang, Xue Zhang, Daochuan Li, Liping Chen, Xiumei Xing, Yongmei Xiao, Wen Chen, Qing Wang*. Mucin2 regulated by Ho1/p38/IL-10 axis plays a protective role in polystyrene nanoplastics-mediated intestinal toxicity. Environmental Pollution. 2023: 121808.
Yangchun Zhang, Ziqi Liu, Ziwei Wang, Huan Gao, Yuqing Wang, Mengxing Cui, Honghao Peng, Yongmei Xiao, Yuan Jin, Dianke Yu, Wen Chen and Qing Wang* Health risk assessment of cadmium exposure by integration of an in silico physiologically based toxicokinetic model and in vitro tests. Journal of Hazardous Materials.2023. 443(Pt A):130191.
Fei Wu, Yangchun Zhang, Xu Chen, Yuqing Wang, Honghao Peng, Zhengbao Zhang, Ying Yang*, Qing Wang*. Bioinformatics analysis of key genes and potential mechanism in cadmium-induced breast cancer progression. Environmental Science and Pollution Research. 2022；29(8):11883-11892
- Yong-Wei Xiong, Yu-Jie Feng, Tian Wei, Xiang Zhang, Lu-Lu Tan, Jin Zhang, Li-Min Dai, Hua-Long Zhua, Guo-Xiang Zhou, Wei-Bo Liu, Zi-Qi Liu, Xiao-Feng Xu, Lan Gao, Cheng Zhang, Qing Wang*, De-Xiang Xu*, Hua Wang*. miR-6769b-5p targets CCND-1 to regulate proliferation in cadmium-treated placental trophoblasts: Association with the impairment of fetal growth. Ecotoxicology and Environmental Safety. 2021；230：113109
- Xu Chen, Yi Tang, Shen Chen, Wen-Hua Ling, and Qing Wang*. IGFBP-2 as a biomarker in NAFLD improves hepatic steatosis:an integrated bioinformatics and experimental study. Endocrine Connections. 2021
- Ye Liu, Cuiju Wen, Yangchun Zhang, Ziqi Liu, Qianmei He, Mengxing Cui, Honghao Peng, Yuqing Wang, Xueying Zhang, Xudong Li, Qing Wang*. Aberrant expression of SNHG12 contributes to N, N-dimethylformamide-induced hepatic apoptosis both in short-term and long-term DMF exposure. Toxicology Research. 2021
- Yangchun Zhang, Ziqi Liu, Qianmei He, Fei Wu, Yongmei Xiao, Wen Chen, Yuan Jin, Dianke Yu and Qing Wang* Construction of Mode of Action for Cadmium-Induced Renal Tubular Dysfunction Based on a Toxicity Pathway-Oriented Approach. Frontiers in Genetics. 2021
- Ziqi Liu, Qianmei He, Ye Liu, Yangchun Zhang, Mengxing Cui, Honghao Peng, Yuqing Wang, Shen Chen, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen, Qing Wang*. Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis. Toxicology. 2021; 458:152838.
- Zhuo-Zhi Liang, Rui-Mei Zhu, Yue-Lin Li, Hong-Mei Jiang, Ruo-Bi Li, Lu-Ying Tang, Qing Wang*, Ze-Fang Ren*. Differential epigenetic and transcriptional profile in MCF-7 breast cancer cells exposed to cadmium. Chemosphere. 2020; 261:128148
Zhen Zhang, Wei Zhu, Ziqi Liua, Ye Liu, Chong Chang, Hongmei Jiang, Ruobi Li, Yongmei Xiao, Wen Chen, Qiansheng Hu*, Qing Wang*. Aberrant expression of miRNA-192-5p contributes to N,N-Dimethylformamide-induced hepatic apoptosis. J Appl Toxicol. 2020; 40 (12), 1683-1693
Hongmei Jiang, Ruobi Li, Zhen Zhang, Chong Chang, Ye Liu, Ziqi Liu, Qianmei He, and Qing Wang*. Retinoid X receptor α (RXRα)-mediated erythroid-2-related factor-2 (NRF2) inactivation contributes to N,Ndimethylformamide (DMF)-induced oxidative stress in HL-7702 and HuH6 cells. J Appl Toxicol. 2020; 40(4):470-482
Zeng N#, Zhang Z#, Jiang H, Li R, Chang C, Wang F, Xu D, Fan Q, Wang T, Xiao Y, Chen W, Shan Z, Huang Z, Wang Q*. LncRNA-241 inhibits 1,2-Dichloroethane-induced hepatic apoptosis. Toxicol In Vitro. 2019; 61:104650.
Liu Z, Cai L, Liu Y, Chen W, Wang Q*. Association between prenatal cadmium exposure and cognitive development of offspring: A systematic review. Environ Pollut. 2019; 254(Pt B):113081.
Wang F#, Chang C#, Li R, Zhang Z, Jiang H, Zeng N, Li D, Chen L, Xiao Y, Chen W, Wang Q*. Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells. Toxicology. 2019; 424:152236
Ni Zeng, Rong Huang, Nan Li, Hongmei Jiang, Ruobi Li, Fei Wang, Wen Chen, Min Xia, Qing Wang*. MiR-451a attenuates free fatty acids–mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene. Mol Cell Endocrinol. 2018; 474:260-271
Fei Wang, Tao Guo, Hongmei Jiang, Ruobi Li, Ting Wang, Ni Zeng, Guanghui Dong, Xiaowen Zeng, Daochuan Li, Yongmei Xiao, Qiansheng Hu, Wen Chen, Xiumei Xing* and Qing Wang*. A comparison of CRISPR/Cas9 and siRNA-mediated ALDH2 gene silencing in human cell lines. Molecular Genetics and Genomics. 2018; 293(3):769-783
Zeng Ni, Jiang Hongmei, Fan Qiming, Wang Ting, Rong Weifeng, Li Guoliang, Li Ruobi, Xu Dandan, Guo Tao, Wang Fei, Zeng Lihai, Huang Manqi, Zheng Jiewei, Lu Fengrong, Chen Wen, Hu Qiansheng, Huang Zhenglie*, Wang Qing*. Aberrant expression of miR-451a contributes to 1,2-dichloroethane-induced hepatic glycerol gluconeogenesis disorder by inhibiting glycerol kinase expression in NIH Swiss mice. J Appl Toxicol. 2018; 38(2):292-303
获奖情况
2009年 参与完成的“动脉粥样硬化的病理机制以及花色苷防治研究”获得广东省科学技术一等奖
2010年 参与完成的“动脉粥样硬化的病理机制以及花色苷防治研究”获得教育部自然科学奖一等奖
2010年 参与完成的“动脉粥样硬化的病理机制以及花色苷防治研究”获得中华医学科技奖二等奖
2016年“膳食多酚类活性物质防治代谢性疾病的基础及应用研究” 中华医学科技奖二等奖
2017年“膳食多酚类活性物质防治代谢性疾病的基础及应用研究” 广东省科技奖二等奖
2017年 第二届“广东省中青年教师公共卫生与预防医学本科课程教学竞赛” 一等奖
实验室简介
实验室的主要研究方向是环境污染物以及食品污染物的风险评估，着重于表观遗传调控模式在化学中毒、化学致癌及风险评估中的应用。实验室通过多种生物技术手段（包括高通量测序技术，生物信息学，分子细胞生物学等），以人、小鼠、体外细胞为研究对象，揭示表观遗传因素在调控毒效应中的作用及作为生物标志在风险评估中的价值。
博士后/特聘副研究员招聘
实验室常年招聘卫生毒理/职业卫生/食品安全方向的博士后或者特聘副研究员。要求为已获得相关专业博士学位，以及有独立从事课题研究的能力，具有强烈的研究兴趣，良好的合作与团队精神。合同为年薪制，年薪23至30万。
研究生招生
实验室欢迎热爱相关研究的优秀学生来了解其硕士和博士研究生招生计划。
