【职称】
副教授
【学位/学历】
医学博士
【工作经历】
2024.06 至今：中山大学，bbin平台
，流行病学系，副教授
2021.09-2024.01: 南方科技大学，公共卫生及应急管理学院，校长卓越博士后。
2019.06-2021.06 布朗大学(Brown University)，bbin平台
，博士后/科研助理
【学习经历】
2015.09-2019.06 兰州大学基础医学院，基础医学/医学大数据分析，医学博士
2016.08-2018.08 耶鲁大学(Yale University)医学院，bbin平台
环境流行病学，国家公派留学
2012.09-2015.06 兰州大学bbin平台
，流行病与卫生统计学，医学硕士
2007.09-2012.06 兰州大学bbin平台
，预防医学，医学学士
【研究方向及兴趣】
慢性病流行病学，环境健康
【论文代表作（近五年）】
1.Qian Dou, Yana Bai, Yongjun Li, Shan Zheng, Minzhen Wang, Zhongge Wang, Jianyun Sun, Desheng Zhang, Chun Yin, Li Ma,
Yongbin Lu, Lizhen Zhang, Ruirui Chen, Zhiyuan Cheng* Perfluoroalkyl substances exposure and the risk of breast cancer: A nested case-control study in Jinchang Cohort. Environmental Research; 2024, 119909.
2. Yang J, Cheng Zhiyuan, Zhang D, Zheng T, Yin C, Liu S, Zhang L, Wang Z, Wang Y, Chen R et al. A nested case-control study of serum zinc and incident diabetes among Chinese adults: Effect modifications and mediation analysis. Science of the Total Environment 2024;910:168678.
3. Wu Y, Cheng Zhiyuan, Zhang W, Yin C, Sun J, Hua H, Long X, Wu X, Wang Y, Ren X. Association between per-and poly-fluoroalkyl substances and nonalcoholic fatty liver disease: A nested case-control study in northwest China. Environmental Pollution 2024;350:123937.
4. Fu-Rong L, Shuang W, Xia L, Cheng Zhiyuan, Cheng J, Chun-Bao M, Zheng J, Liang F-C, Dong-Feng G. Multimorbidity and mortality among older patients with coronary heart disease in Shenzhen, China. Journal of Geriatric Cardiology: JGC 2024;21:81.
5. Zhang L, Wang Z, Chen R, Cheng Zhiyuan, Yang J, Li J, Li S, Chen Y, Xu L, Hu Y. Fasting plasma glucose and alanine aminotransferase on the risk of hepatocellular carcinoma: a nested case-control study. Cancer Epidemiology 2023;84:102362.
6. Yang J, Lu Y, Bai Y, Cheng Zhiyuan*. Sex‐specific and dose‐response relationships of urinary cobalt and molybdenum levels with glucose levels and insulin resistance in US adults. Journal of Environmental Sciences 2023;124:42-49.
7. Lu Y#, Su F#, Cheng Zhiyuan#, Yang J, Dai H, Yang J, Zhang T, Bai Y. Nickel chloride promotes lung cancer invasion and metastasis by up-regulating the expression of E3 ubiquitin ligase TRIM31 through the IL-6/STAT3 signaling axis. Life Sciences 2023;332:122111.
8. Li FR, Liao J, Zhu B, Li X, Cheng Zhiyuan, Jin C, Mo C, Wu X, Li Q, Liang F. Long‐term exposure to air pollution and incident non‐alcoholic fatty liver disease and cirrhosis: A cohort study. Liver International 2023;43:299-307.
9. Hu Y, Li J, Yin C, Xu L, Li S, Chen Y, Wang Y, Cheng Zhiyuan, Bai Y*. Mediating effect of metabolic diseases on the relationship between hyperuricemia and coronary heart disease. Nutrition, Metabolism and Cardiovascular Diseases 2023;33:315-322.
10. Chen Y, Xu L, Cheng Zhiyuan*, Zhang D, Yang J, Yin C, Li S, Li J, Hu Y, Wang Y. Progression from different blood glucose states to cardiovascular diseases: a prospective study based on multi-state model. European Journal of Preventive Cardiology 2023;30:1482-1491.
11. Zheng S, Luo Y, Miao Q, Cheng Zhiyuan, Liu Y, Lv K, Zhang D, Yin C, Wang M, Bai Y. Serum uric acid levels and their changes and risk of stroke: a 7-year prospective cohort study in Northwest China. Cerebrovascular Diseases 2022;51:225-234.
12. Zhang R, Bai Y, Wang R, Bai Z, Yang J, Chen Y, Li J, Xu L, Li S, Hu Y, Cheng Zhiyuan*. Elevated serum bilirubin may significantly reduce coronary heart disease risk in females: A prospective cohort study. Nutrition, Metabolism and Cardiovascular Diseases 2022;32:648-657.
13. Wang R, Bai Z, Zhang D, Zhang R, Yang J, Yin C, Huang W, Huang P, Wang Y, Liu N, Cheng Zhiyuan*. Mediating effects of insulin resistance on the development of hypertension associated with elevated serum uric acid: a prospective cohort study. Journal of Human Hypertension 2022;36:760-766.
14. Li F-R, Zhu B, Liao J, Cheng Zhiyuan, Jin C, Mo C, Liang F. Ambient air pollutants and incident microvascular disease: a cohort study. Environmental Science & Technology 2022;56:8485-8495.
15. Cheng Zhiyuan, Li Y, Young JL, Cheng N, Yang C, Papandonatos GD, Kelsey KT, Wise Sr JP, Shi K, Zheng T. Long-term association of serum selenium levels and the diabetes risk: Findings from a case-control study nested in the prospective Jinchang Cohort. Science of the Total Environment 2022;818:151848.
16. Bai Y, Yang J, Cheng Zhiyuan, Zhang D, Wang R, Zhang R, Bai Z, Zheng S, Wang M, Yin C. Cohort profile update: the China metal-exposed workers cohort study (Jinchang Cohort). European Journal of Epidemiology 2022;37:641-649.
17. Zheng S, Zhu W, Shi Q, Wang M, Nie Y, Zhang D, Cheng Zhiyuan, Yin C, Miao Q, Luo Y. Effects of cold and hot temperature on metabolic indicators in adults from a prospective cohort study. Science of The Total Environment 2021;772:145046.
18. Zheng S, Wang MZ, Cheng Zhiyuan, Feng K, Nie YH, Mi XY, Li HY, Lan J, Zhang YW, Bai YN. Effects of outdoor temperature on blood pressure in a prospective cohort of northwest China. Biomedical and Environmental Sciences 2021;34:89-100.
19. Cheng Zhiyuan, Zheng T, Zhang D, Yang J, Hu X, Yin C, Ren X, Li J, Shi D, Li N. High-level uric acid in asymptomatic hyperuricemia could be an isolated risk factor of cardio-cerebrovascular diseases: A prospective cohort study. Nutrition, Metabolism and Cardiovascular Diseases 2021;31:3415-3425.
20. Cheng Zhiyuan, Zheng T, Zhang D, Yang J, Hu X, Yin C, Ren X, Li J, Li N, Zheng S. High-level Exposure of Uric Acid in Asymptomatic Hyperuricemia Could Be An Isolated Risk Factors of Cardio-Cerebrovascular Diseases: A Prospective Cohort Study. 2021.
21. Cheng Zhiyuan, Zhang X, Bassig B, Hauser R, Holford TR, Zheng E, Shi D, Zhu Y, Schwartz SM, Chen C. Serum polychlorinated biphenyl (PCB) levels and risk of testicular germ cell tumors: a population-based case-control study in Connecticut and Massachusetts. Environmental Pollution 2021;273:116458.
22. Cheng Zhiyuan, Zhang X, Bassig B, Hauser R, Holford TR, Zheng E, Shi D, Zhu Y, Schwartz SM, Chen C. Dataset of testicular germ cell tumors (TGCT) risk associated with serum polychlorinated biphenyl (PCB) by age at diagnosis and histologic types. Data in Brief 2021;36:107014.
23. Gan T, Cheng N, Ding J, Cheng Zhiyuan, Zhang D, Li H, Li J, Li N, Yang A, Ren X. Effects of hepatitis B virus infection, alanine aminotransferase, aspartate aminotransferase and gamma-glutamyl transferase on prediabetes and diabetes mellitus: A cohort study. Annals of Hepatology 2020;19:197-203.
24. Ren XY, Shi D, Ding J, Cheng Zhiyuan, Li HY, Li JS, Pu HQ, Yang AM, He CL, Zhang JP. Total cholesterol to high-density lipoprotein cholesterol ratio is a significant predictor of nonalcoholic fatty liver: Jinchang cohort study. Lipids in health and disease 2019;18:1-7.
25. Cheng Zhiyuan, Cheng N, Shi D, Ren X, Gan T, Bai Y, Yang K. The relationship between Nkx2. 1 and DNA oxidative damage repair in nickel smelting workers: Jinchang cohort study. International journal of environmental research and public health 2019;16:120.
【研究项目】
1. 某集团职工代谢病疾病至CVD全病程及影响因素研究， 2024年-2025年，子项目PI
2. 多金属暴露诱发肺癌发病的交互作用及其机制的巢式病例对照研究 博士后第71批面上基金， 2021年-2024， PI
3. 中山大学引进人才基本启动经费, 2024年-2027, PI
4. 美国国立卫生研究院 (The U.S. National Institute of Health), A nested case-control study of exposure to toxic metals, essential metals and their interaction on the risk of type 2 diabetes)》(NIH Grant Number: 1R01ES029082)，2019-2024，主要参与人员。
【获奖情况】
“挑战杯”甘肃省大学生课外学术科技作品竞赛 特等奖 (1/3)，等
【社会兼职】
深圳市分析测试协会 委员
【研究生培养情况】
每年招收全日制硕士研究生
