【个人简历】

郭城博士多年来聚焦病原组学检测技术的创新，以及其在新发和不明原因感染性疾病研究中的应用，包括：①发明病原捕获测序和高通量血清学检测技术，利用创新的探针设计、样本处理体系和生信分析流程，使新方法的灵敏度较传统方法提升近千倍；②在临床或自然场景中开展新发传染病的检测和风险预警研究，助力公共卫生政策的调整；③鉴定以慢性疲劳综合征为代表的不明原因感染性疾病的肠道细菌生物标志物，揭示了丁酸盐产生菌在疾病进展中的作用。近年来在Cell Host Microbe，Lancet Gastroenterol等杂志发表论文40余篇，被引用3500余次，获批多项与病原检测相关的美国发明专利。相关科研成果曾被国家新冠防控指南引用、以及时代杂志、纽约日报、财新新闻等100多家新闻媒体报道。

课题组主页：//lab.chengguo-sysu.cn/

 

【工作经历】
2024至今，中山大学，bbin平台 ，副教授
2022/10-2024，哥伦比亚大学(Columbia University)，bbin平台 ，感染免疫研究中心生信团队负责人(Head of Bioinformatics)
2016/05-2024/03，哥伦比亚大学，bbin平台 ，高级生信研究员(Senior Programmer Analyst/Bioinformatics)
2015/01-2016/05，美国国家环境保护署(EPA)，生物信息师(Bioinformatician)

 

【学习经历】
2011/09-2016/10，迈阿密大学(Miami University), 生物信息学，博士
2008/09-2011/06，中国药科大学，药物生物信息学，硕士
2004/09-2008/06，中国药科大学，生命科学基地班，学士

 

【研究生招生与博士后招聘】
博士/硕士研究生 (方向：公共卫生与预防、医学流行病与卫生统计学、公共卫生硕士MPH等相关学科)
博士后 (方向：病原学、微生物组、生物信息学等相关学科)

 

【近年论文代表作】

  • C. Guo, J. Y. Wu. Pathogen Discovery in the Post-COVID Era. Pathogens, 2024, 13(1)
  • X Li, C Liao, J Wu, B Yi, R Zha, Q Deng, J Xu, C Guo#, J Lu#, Distinct serum exosomal miRNA profiles detected in acute and asymptomatic dengue infections: A community-based study in Baiyun District, Guangzhou, Heliyon 10 (10)
  • C. Guo, X. Che, T. Briese, A. Ranjan, O. Allicock, R. A. Yates et al. Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS. Cell Host Microbe, 2023, 31(2): 288-304.e8
  • C. Guo, B. Yi, J. Wu, J. Lu. The microbiome in post-acute infection syndrome (PAIS). Computational and structural biotechnology journal, 2023, 21: 3904-3911
  • Q. Wu*, C. Guo*, X. K. Li, B. Y. Yi, Q. L. Li, Z. M. Guo et al. A meta-transcriptomic study of mosquito virome and blood feeding patterns at the human-animal-environment interface in Guangdong Province, China. One health (Amsterdam, Netherlands), 2023, 16: 100493
  • X. Cheng, Y. Zhang, Y. Li, Q. Wu, J. Wu, S. K. Park, C. Guo#, J. Lu#. Meta-analysis of 16S rRNA microbial data identified alterations of the gut microbiota in COVID-19 patients during the acute and recovery phases. BMC Microbiology, 2022, 22(1): 1-13
  • Y. Wu, X. Cheng, G. Jiang, H. Tang, S. Ming, L. Tang, C. Guo#, H. Shan#, X. Huang#. Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization. NPJ biofilms and microbiomes, 2021, 7(1): 61
  • J. Y. Wu*, C. Guo*, Y. Xia, H. M. Bao, Y. S. Zhu, Z. M. Guo et al. Genomic characterization of Wenzhou mammarenavirus detected in wild rodents in Guangzhou City, China. One health (Amsterdam, Netherlands), 2021, 13: 100273
  • J. Wang*, C. Guo*, L. Cai, C. Liao, H. Yi, Q. Li et al. Pre-Existing Cross-Reactive Antibody Responses Do Not Significantly Impact Inactivated COVID-19 Vaccine-Induced Neutralization. Frontiers in immunology, 2021, 12: 772511
  • J. Y. Wu*, Y. S. Zhu*, C. Guo*, Y. Xia, Z. M. Guo, Q. L. Li et al. A Comparative Study of Associated Microbiota Between Pig Farm and Pig Slaughterhouse in Guangdong, China. Current microbiology, 2020, 77(11): 3310-3320
  •  Y. Wu*, C. Guo*, L. Tang, Z. Hong, J. Zhou, X. Dong et al. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. The lancet. Gastroenterology & hepatology, 2020, 5(5): 434-435
  •  M. Allicock*, C. Guo*, A. C. Uhlemann, S. Whittier, L. V Chauhan, J. Garcia et al. BacCapSeq: a Platform for Diagnosis and Characterization of Bacterial Infections. mBio, 2018, 9(5)
  •  C. Guo, M. Spinelli, M. Liu, Q. Q. Li, C. Liang. A Genome-wide Study of “Non-3UTR” Polyadenylation Sites in Arabidopsis thaliana. Scientific Reports, 2016, 6: 28060
  •  C. Guo, M. Spinelli, C. Ye, Q. Q. Li, C. Liang. Genome-Wide Comparative Analysis of Miniature Inverted Repeat Transposable Elements in 19 Arabidopsis thaliana Ecotype Accessions. Scientific reports, 2017, 7(1): 2634
  •  L. Li*, C. Guo*, C. Liang, X. Wang. RNAi-mediated transgenic rice resistance to Rice stripe virus. Journal of integrative Agriculture, 2016, 23
  •  C. Guo, L. Li, X. Wang, C. Liang. Alterations in SiRNA and MiRNA Expression Profiles Detected by Deep Sequencing of Transgenic Rice with SiRNA-Mediated Viral Resistance. PLOS ONE, 2015, 10(1): e0116175
  •  L. Ma, C. Guo, Q. Q. Li. Role of alternative polyadenylation in epigenetic silencing and antisilencing. Proceedings of the National Academy of Sciences, 2014, 111(1): 9-10