职称
预聘助理教授（副教授职务），博士生导师，硕士生导师。
获聘中山大学“逸仙学者计划-新锐学者”岗位。
电子邮箱： [email protected]
个人学术网站: //rocketjishao.github.io/
学术简历：
【教育经历】
2017/8-2021/4：香港浸会大学 化学 博士学位
2013/8-2016/6：清华大学 化学生物学 硕士学位
2009/8-2013/6：南开大学 分子科学与工程 学士学位
【工作经历】
2024/1-至今：中山大学 公卫学院 预聘助理教授（副教授职务）
2021/6-2024/1：香港大学 化学系 博士后
2016/7-2017/7：香港浸会大学 环境与生物分析国家重点实验室 研究助理
研究方向
将化学生物学方法与多组学技术相结合，开发方法以应用于毒理学研究，包括：
1）应用多种化学蛋白组学方法，来研究环境污染物、金属类药物的靶蛋白，从而了解其作用机制。
2）开发了新的表观转录组学方法——tagSeq策略，来研究RNA的非典型加帽修饰，如dpCoA和 NAD+。以期了解环境污染物对RNA加帽修饰的调节。
以第一作者身份在Nature Protocols、Chemical Science、Analytical Chemistry、Analytica Chimica Acta等国际权威学术期刊发表多篇SCI论文。
主要承担或参与的课题：
1. 国家自然科学基金委员会，青年科学基金项目，21705136，发展化学蛋白质组学平台用于筛选天然产物的靶蛋白，2018-01-01至2020-12-31，25万元，结题，参与
获奖情况：
2021年北美华人色谱学会，优秀学生奖
2017年-2020年香港政府博士生奖学金
2020年中国分析测试协会科学技术奖CAIA奖，特等奖，第7主要完成人
论文代表作：
(1) Shao Xiaojian, Xing Fangrong, Zhang Yiwei, Lok Chun-Nam, Che Chi-Ming*. Integrative chemoproteomics reveals anticancer mechanisms of silver(i) targeting the proteasome regulatory complex. Chemical Science 2024.
(2) Shao Xiaojian, Zhang Hailei, Zhu Zhou, Ji Fenfen, He Zhao, Yang Zhu*, Xia Yiji*, Cai Zongwei*. DpCoA tagSeq: barcoding dpCoA-capped RNA for direct nanopore sequencing via maleimide-thiol reaction. Analytical Chemistry 2023, 95, 11124-11131.
(3) Shao Xiaojian, Zhang Hailei, Zhu Zhou, Ji Fenfen, He Zhao, Yang Zhu*, Xia Yiji*, Cai Zongwei*. Response to the comment on "DpCoA tagSeq: barcoding dpCoA-capped RNA for direct nanopore sequencing via maleimide-thiol reaction". Analytical Chemistry 2023, 96, 610-613.
(4) Zhang Hailei, Zhong Huan, Wang Xufeng, Zhang Shoudong, Shao Xiaojian, Hu Hao, Yu Zhiling, Cai Zongwei, Chen Xuemei*, Xia Yiji*. Use of NAD tagSeq II to identify growth phase-dependent alterations in E. coli RNA NAD+ capping. Proceedings of the National Academy of Sciences 2021, 118.
(5) Shao Xiaojian, Zhang Hailei, Yang Zhu, Zhu Lin, Cai Zongwei*. Quantitative profiling of protein-derived electrophilic cofactors in bacterial cells with a hydrazine-derived probe. Analytical Chemistry 2020, 92, 4484-4490.
(6) Shao Xiaojian, Zhang Hailei, Yang Zhu, Zhong Huan, Xia Yiji*, Cai Zongwei*. NAD tagSeq for transcriptome-wide identification and characterization of NAD+-capped RNAs. Nature Protocols 2020, 15, 2813-2836.
(7) Zhang Hailei, Zhong Huan, Zhang Shoudong, Shao Xiaojian, Ni Min, Cai Zongwei, Chen Xuemei*, Xia Yiji*. NAD tagSeq reveals that NAD+-capped RNAs are mostly produced from a large number of protein-coding genes in Arabidopsis. Proceedings of the National Academy of Sciences 2019, 116, 12072-12077.
(8) Zhang Hongna, Shao Xiaojian, Zhao Hongzhi, Li Xiaona, Wei Juntong, Yang Chunxue, Cai Zongwei*. Integration of metabolomics and lipidomics reveals metabolic mechanisms of triclosan-induced toxicity in human hepatocytes. Environmental Science & Technology 2019, 53, 5406-5415.
(9) Li Dapeng, Zhang Jinghui, Xie Guangshan, Ji Fenfen, Shao Xiaojian, Zhu Lin, Cai Zongwei*. A dual-zwitterion functionalized ultra-hydrophilic metal–organic framework with ingenious synergy for enhanced enrichment of glycopeptides. Chemical Communications 2019, 55, 13967-13970.
(10) Ji Fenfen, Sreenivasmurthy Sravan Gopalkrishnashetty, Wei Juntong, Shao Xiaojian, Luan Hemi, Zhu Lin, Song Juxian, Liu Liangfeng, Li Min, Cai Zongwei*. Study of BDE-47 induced Parkinson's disease-like metabolic changes in C57BL/6 mice by integrated metabolomic, lipidomic and proteomic analysis. Journal of Hazardous materials 2019, 378, 120738.
(11) Shao Xiaojian, Ji Fenfen, Wang Yawei, Zhu Lin, Zhang Zhen, Du Xiubo, Chung Arthur Chi Kong, Hong Yanjun, Zhao Qian, Cai Zongwei*. Integrative chemical proteomics-metabolomics approach reveals Acaca/Acacb as direct molecular targets of PFOA. Analytical Chemistry 2018, 90, 11092-11098.
(12) Shao Xiaojian, Gao Dan*, Chen Yongli, Jin Feng, Hu Guangnan, Jiang Yuyang, Liu Hongxia*. Development of a blood-brain barrier model in a membrane-based microchip for characterization of drug permeability and cytotoxicity for drug screening. Analytica Chimica Acta 2016, 934, 186-193.
(13) Shao Xiaojian, Gao Dan*, Wang Yini, Jin Feng, Wu Qin, Liu Hongxia*. Application of metabolomics to investigate the antitumor mechanism of flavopiridol in MCF-7 breast cancer cells. Journal of Chromatography B 2016, 1025, 40-47.
