学术简历
1984.9-1990.7上海医科大学 预防医学系预防医学专业本科,获医学学士学位
1996.9-1998.7中山医科大学 劳动卫生职业病与卫生毒理学专业硕士研究生
1998.9-2001.7中山医科大学 卫生毒理学专业博士研究生,获医学博士学位
2001.7-2004.4中山(医科)大学 讲师
2004.5-2006.9 中山大学 副教授/硕士导师
2004.12-2006.12 美国耶鲁大学 博士后
2007.1-2011.12美国耶鲁大学 助理研究员
2011.12- 中山大学“百人计划”引进人才 教授/博士生导师
社会兼职
★国家级和省级专业学会任职:
1)中国毒理学会理事;
2)中国环境诱变剂学会理事;
3)中国毒理学会遗传毒理学专业委员会副主任委员
4)广东省毒理学会常务理事;
5)广东省环境诱变剂学会理事;
6)广东省预防医学会毒理学专业委员会委员
★国家医学考试中心专家委员会专家
★国家级和省级杂志担任编委:
1)《中华预防医学杂志》编委;
2)《癌变畸变突变》杂志编委;
3)《环境与职业医学》杂志编委;
4)《中国职业医学》杂志编委;
5)《华南预防医学杂志》编委;
6)《环境科学学报》编委。
★SCI杂志审稿人
1)environmental toxicology and pharmacology
2)Chinese Journal of Cancer
主要承担或参与的课题
1. 心血管发育毒性相关基因和毒物筛查及毒性通路研究 国家自然科学基金(编号81472998) 2015.1-2018.12(主持人、在研)
2. CCM3基因缺陷小鼠铅暴露模型及人群遗传易感性研究 国家自然科学基金(编号81273097) 2013.1-2016.12(主持人、在研)
3. 具有心血管毒性的环境化学污染物的筛查 中山大学“百人计划”引进人才科研启动基金项目 2012.1-2014.1(主持人、在研)
4. DNA修复酶MSH2缺陷对苯代谢产物遗传毒性的影响 国家自然科学基金(编号30200230)(主持人)2003.1~2005.12
5. DNA修复酶MSH2缺陷与肿瘤发生的关系 广东省自然科学基金(编号021816)(主持人)2003.1~2005.12
6.环境化学污染物(ECPs)致DNA损伤及其修复与遗传通路的研究 国家重点基础研究发展规划项目(973计划)子项目(编号:2002CB512903)(第二负责人)2003.1~2007.12
近期发表的主要文章
1. Gao Y, Yin Y, Xing X, Zhao Z, Lu Y, Sun Y, Zhuang Z, Wang M, Ji W, He Y*. Arsenic-induced anti-angiogenesis via miR-425-5p-regulated CCM3. Toxicol Lett. 2016, 254: 22-31. (*通讯作者)
2. Ji W, Li Y, He Y*, Yin M, Zhou HJ, Boggon TJ, Zhang H, and Min W. AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis. Cancer Res, 2015, 75(17):3492-504. (*共同第一)
3. He Y*, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W. Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development. Science Signaling,2010;3(116):ra26. (《科学杂志》子刊)(*第一作者)
4. He Y*, Luo Y, Tang S, Rajantie I, Salven P, Heil M, Zhang R, Luo D, Li X, Chi H, Yu J, Carmeliet P, Schaper W, Sinusas AJ, Sessa WC, Alitalo K, Min W. Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis. J Clin. Invest, 2006;116(9):2344-2455. (*第一作者)
5. He Y*, Zhang W, Zhang R, Zhang H, and Min W. SOCS1 Inhibits Tumor Necrosis Factor-induced Activation of ASK1-JNK Inflammatory Signaling by Mediating ASK1 Degradation. J Biol Chem,2006;2819(9):5559-5566. (*第一作者)
6. Zhang H, He Y*, Dai S, Xu Z, Luo Y, Wan T, Luo D, Jones D, Tang S, Chen H, Sessa WC, Min W. AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. J Clin Invest,2008;118(12):3904-16. (*共同第一)
7. Qi D, Hu Y, Li J, Peng T, Su J, He Y*, Ji W. Hyperthermia Induces Apoptosis of 786-O Cells through Suppressing Ku80 Expression. PLoS One,2015;10(4):e0122977. (*共同通讯)
8. Dai S, He Y*, Zhang H, Yu L, Wan T, Xu Z, Jones D, Chen H, Min W. Endothelial-specific expression of mitochondrial thioredoxin promotes ischemia-mediated arteriogenesis and angiogenesis. Arterioscler Thromb Vasc Biol, 2009;29(4):495-502. (*共同第一)
9. Luo D, LuoY, He Y*, Zhang H, Zhang R, Li X, Dobrucki WL, Sinusas AJ, Sessa WC, Min W.. (2006) .Differential functions of TNFR1 and TNFR2 signaling in ischemia -mediated arteriogenesis and angiogenesis. Am J Pathol, 2006;169(5):1886-1898. (*共同第一)
10. Zhang H, Zhang W, Luo Y, He Y, Zhang R, Min W, et al. Endothelial-Specific Expression of Mitochondrial Thioredoxin Improves Endothelial Cell Function and Reduces Atherosclerotic Lesions. Am J Pathol,2007;170:1108-1120 (*共同第一)
11. Luo D, He Y, Zhang H, Yu L, Chen H, Xu Z, Tang S, Urano F, Min W. AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. J Biol Chem,2008;283(18):11905-12.
12. Yu L, Min W, He Y, Qin L, Zhang H, Bennett AM, Chen H. JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1. J Biol Chem,2009;284(20):13481-8.
13. Li X, Zhang R, Zhang H, He Y, Ji W, Min W, Boggon TJ. Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. J Biol Chem,2010;285(31):24099-107.
14. Yu L, Ji W, Zhang H, Renda MJ, He Y, Lin S, Cheng EC, Chen H, Krause DS, Min W. SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. J Exp Med,2010;207(6):1183-95.
15. Luo Y, Xu Z, Wan T, He Y, Zhang H, Min W. Endothelial-Specific Transgenesis of TNFR2 Promotes Adaptive Arteriogenesis and Angiogenesis. Arterioscler Thromb Vasc Biol,2010;30(7):1307-14.
16. Li X, Luo Y, Yu L, Lin Y, Luo D, Zhang H, He Y, Kim YO, Kim Y, Tang S, Min W. SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. Cell Death Differ,2008;15(4):739-50.
17. Yu L, Qin L, Zhang H, He Y, Chen H, Pober JS, Tellides G, Min W. AIP1 prevents graft arteriosclerosis by inhibiting interferon-γ-dependent smooth muscle cell proliferation and intimal expansion. Circ Res,2011;109(4):418-27.
18. Jones D, Xu Z, Zhang H, He Y, Kluger MS, Chen H, Min W. Functional analyses of the bone marrow kinase in the X chromosome in vascular endothelial growth factor-induced lymphangiogenesis. Arterioscler Thromb Vasc Biol,2010;30(12):2553-61.
19. Min W, Xu LK, Zhou HJ, Huang Q, Zhang H, He Y, Zhe X, Luo Y. Thioredoxin and redox signaling in vasculature-studies using Trx2 endothelium-specific transgenic mice. Methods Enzymol,2010;474:315-24.
20. Fang DK, He Y, Zhang JQ, Hu DL, Sha Y, Zhuang ZX. X-ray repair cross complementing group 1 protects human bronchial epithelial cells from hydroquinone-induced DNA damage. Chinese Journal of Pharmacology and Toxicology,2009;23(2):89-98.
21. Holopainen T, López-Alpuche V, Zheng W, Heljasvaara R, Jones D, He Y, Tvorogov D, D'Amico G, Wiener Z,Andersson LC, Pihlajaniemi T, Min W, Alitalo K. Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Res. 2012 Jul 15;72(14):3512-21.
22. Jones D, Li Y, He Y, Xu Z, Chen H, Min W. Mirtron microRNA-1236 inhibits VEGFR-3 signaling during inflammatory lymphangiogenesis. Arterioscler Thromb Vasc Biol. 2012 Mar; 32(3):633-42.
研究生培养情况
博士生:4名
科研型硕士:12名
公共卫生硕士:6名
招生专业
卫生毒理学
获奖情况
(1)获得第三届亚洲毒理学会国际会议“Outstanding Achievement Young Scientist Presentation Award”;
(2)获得第五届耶鲁大学“Vascular Biology&Transplantation Retreat Best Poster Prize”;
(3)获得第六届耶鲁大学“Vascular Biology&Transplantation Retreat Best Poster Prize”;
(4)入选中山大学“百人计划”