【职 称】 教授（博士生导师）
【所属部门】 卫生毒理学系
【电子邮件】 [email protected]
【研究方向】（主要研究领域）
分子与遗传毒理学
【学术简历】
2005年作为人才引进受聘于bbin平台-bbin官网-bbin电子 ，长期致力于遗传毒理学和环境化学致癌机理方面的研究。获得国家杰出青年基金（2009年）；主持国家自然科学基金重点项目4项；主持国家重点研发计划项目（课题负责人）；参与国家重点基础研究计划(973)项目、863重大项目、卫生部公益项目、科技部支撑计划项目等课题的研究。入选“珠江学者”特聘教授；获中国毒理学杰出贡献奖，《毒理学基础》教材副主编。在国内外杂志发表论文300余篇，其中SCI收录文章100+篇。主要研究方向是：人体细胞转化模型建立和应用；环境致癌表观遗传机制以及人群生物标记物研究；DNA损伤修复以及氧化损伤的表观遗传调控机制。
【社会兼职】
1. 中国毒理学会副理事长
2. 中国环境诱变剂学会副理事长
3. 《Food Chem Toxicol 》共同主编
4.《Environ Pollut 》副主编
5.《中华预防医学杂志》副总编
6. 环保部化学物质环境管理评审专家
【主要承担的课题】
1. 臭氧暴露对机体损伤的表观遗传时钟和毒性通路扰动的分子机制 国家自然科学基金重点项目 （课题主持人 2022-2026, 82130094）
2. 大气细颗粒物健康危害的系统毒理学与系统流行病学研究 国家自然科学基金重大研究计划集成项目（课题组成员 2020-2022, 91943301）
3. 交通源超细颗粒物暴露与神经退行性疾病风险评估的关键技术及应用 国家重点研发计划 (骨干 2019.7.1-2022.6.30)
4. 食品典型污染物低剂量暴露的毒作用模式研究 国家重点研发计划（课题主持人 2018-2021）
5. 基于AOP框架构建大气细颗粒物暴露致肺癌的风险评估模式 广东省团队项目（课题主持人 2018-2023）
6. 基于毒性通路的大气细颗粒物暴露致肺癌机制研究国家自然科学基金重大研究计划重点项目（课题主持人 2016-2019）
7. 职业低浓度苯暴露的血液毒性机制和毒作用模式研究 国家自然科学基金重点项目 （课题主持人 2015-2019）
8. 化学致癌表观遗传调控模式研究 国家杰出青年基金（课题主持人 2010-2013）
9. 职业卫生检测与健康监护技术研究 卫生公益性行业科研专项 （单元负责人 2010-2013）
10. 恶性肿瘤非编码RNA相关蛋白的功能网络与调控机制的研究 国家重点基础研究计划(973)项目 (骨干 2010-2014)
11. 环境遗传毒性物质暴露和效应评估关键技术 863计划重大专项（分题负责人 2008-2011）
12. 环境化学污染物诱导细胞转化的表观遗传机制. 国家自然科学基金重点项目 （课题主持人 2007-2010, 30630055）
【发表的主要论著】(代表作)
1. Ziwei Wang, Shen Chen, Yaqin Pang, Lizhu Ye, Qi Zhang, Xinhang Jiang, Rui Zhang, Miao Li, Zhanyu Guo, Yue Jiang, Daochuan Li, Xiumei Xing, Liping Chen, Michael Aschner*, Wen Chen*. Morphological alterations in C57BL/6 mouse intestinal organoids as a tool for predicting chemical induced toxicity. Arch Toxicol, 2023, 97:1133-1146.
2. Rui Zhang, Shen Chen, Ziwei Wang, Lizhu Ye, Yue Jiang, Miao Li, Xinhang Jiang, Hui Peng, Zhanyu Guo, Liping Chen, Rong Zhang, Yujie Niu, Michael Aschner, Daochuan Li*, and Wen Chen*. Assessing the Effects of Nicotinamide Mononucleotide Supplementation on Pulmonary Inflammation in Male Mice Sub-chronically Exposed to Ambient Particulate Matter. Environ Health Perspect, 2023; 131(7):77006.
3. Shen Chen, Miao Li, Rui Zhang, Lizhu Ye, Yue Jiang, Xinhang Jiang, Hui Peng, Ziwei Wang, Zhanyu Guo, Liping Chen, Rong Zhang, Yujie Niu, Michael Aschner, Daochuan Li, Wen Chen*. Type 1 diabetes and diet-induced obesity predispose C57BL/6J mice to PM2.5-induced lung injury: a comparative study. Particle Fibre Toxicol, 2023, 20（1）:10.
4. Liping Chen, Ping Guo, Wenxue Li, Xinhang Jiang, Qun Zhao, Daochuan Li，Qing Wang, Yongmei Xiao, Xiumei Xing, Michael Aschner, Lihua Zhang*, and Wen Chen*. Identification of Protein Phosphatase 2A-regulated Hepatic Metabolic Enzymes in Response to Xenobiotics. J Biol Chem, 2022; 298(5):101918.
5. Rui Zhang, Shen Chen, Liping Chen, Lizhu Ye, Yue Jiang, Hui Peng, Zhanyu Guo, Miao Li, Xinhang Jiang, Ping Guo, Dianke Yu, Rong Zhang, Yujie Niu, Yuan Zhuang, Michael Aschner, Yuxin Zheng, Daochuan Li*, and Wen Chen*. Single-cell transcriptomics reveals immune dysregulation mediated by IL-17A in initiation of chronic lung injuries upon real-ambient particulate matter exposure. Part Fibre Toxicol, 2022; 19:42.
6. Lizhu Ye, Zhini He, Daochuan Li, Liping Chen, Shen Chen, Ping Guo, Dianke Yu, Yong Niu, Huawei Duan, Xiumei Xing, Yongmei Xiao, Xiaowen Zeng, Qing Wang, Guanghui Dong, Michael Aschner, Yuxin Zheng*, Wen Chen*. CpG sites-specific methylation as epi-biomarkers for prediction of health risk in PAH-exposed populations. J Hazard Mater, 2022; 5; 431:128538.
7. Lizhu Ye, Zhini He, Daochuan Li, Liping Chen, Shen Chen, Ping Guo, Dianke Yu, Yong Niu, Huawei Duan, Xiumei Xing, Yongmei Xiao, Xiaowen Zeng, Qing Wang, Guanghui Dong, Michael Aschner, Yuxin Zheng*, Wen Chen*. CpG sites-specific methylation as epi-biomarkers for prediction of health risk in PAH-exposed populations. J Hazard Mater, 2022; 5; 431:128538.
8. Shen Chen, Daochuan Li, Xiaonen Wu, Liping, Chen, Bin Zhang, Yafei Tan, Dianke Yu, Yong Niu, Huawei Duan, Qiong Li, Rui Chen, Michael Aschner, Yuxin Zheng, Wen Chen*. The Application of Cell-based Biological Endpoints for Health Risk Assessment of PM2.5 Exposure in Three Megacities, China. Environ Int, 2020; 139:105703.
9. Daochuan Li, Shen Chen, Qiong Li, Liping Chen, Haiyan Zhang, Huiyao Li, Dianke Yu, Rong Zhang, Yujie Niu, Shaoyou Lu, Lizhu Ye, Xiaowen Zeng, Guanghui Dong, Rui Chen, Michael Aschner, Yuxin Zheng, Wen Chen*. Caloric restriction attenuates C57BL/6J mouse lung injury and extra-pulmonary toxicity induced by real ambient particulate matter exposure. Part Fibre Toxicol, 2020;17: 22.
10. Chen S, Li DC, Zhang HY, Yu, DK, Chen R, Zhang B, Tan YF, Niu Y, Duan HW, Mai BX, Chen, SJ, Yu JZ, Luan TG, Chen LP, Xing XM, Li Q, Xiao YM, Dong GH, Niu YJ, Michael Aschner, Zhang R, Zheng YX, Chen W*. The Development of a Cell-based Model for The Assessment of Carcinogenic Potential Upon Long-term PM2.5 Exposure. Environ Int. 2019; 131:104943.
11. Liang B, Chen Y, Yuan W, Qin F, Zhang Q, Deng N, Liu X, Ma X, Zhang X, Zhang B, Deng Q, Huang M, Tang H, Liu L, Chen W*, Xiao Y*. Down-regulation of miRNA-451a and miRNA-486-5p Involved in Benzene-induced Inhibition on Erythroid Cell Differentiation In Vitro And In Vivo. Arch Toxicol. 2018; 92:259-272.
12. Li H, Li D, He Z, Fan J, Li Q, Liu X, Guo P, Zhang H, Chen S, Li Q, Zhang R, Xing X, Zeng X, Zhang A, Tang H, Dong G, Wang Q, Xiao Y, Chen L*, Chen W*. The Effects of Nrf2 Knockout on Regulation of Benzene-induced Mouse Hematotoxicity. Toxicol Appl Pharmacol, 2018; 358:56-67.
13. Zhini He, Daochuan Li, Junxiang Ma, Liping Chen, Huawei Duan, Bo Zhang, Chen Gao, Jie Li, Xiumei Xing, Jian Zhao, Shan Wang, Fangping Wang, Haiyan Zhang, Huiyao Li, Shen Chen, Xiaowen Zeng, Qing Wang, Yongmei Xiao, Yuxin Zheng, Wen Chen*. TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation. Environ Pollution, 2017; 225:93-103.
14. Lu Ma, Jun Li, Zhengbao Zhang, Liping Chen, Daochuan Li, Qing Bai, Chen Gao, Jie Li, Xiaowen Zeng, Zhine He, Shang Wang, Yongmei Xiao, Wen Chen*, Aihua Zhang*. Specific Histone Modification Responds to Arsenic-induced Oxidative Stress. Toxicol Appl Pharmacol, 2016; 302:52-61.
15. LP Chen, L Ma, Q Bai, XN Zhu, JM Zhang, Q Wei, DC Li, C Gao, ZB Zhang, CX Liu, ZN He, XW Zeng, AH Zhang, WD Qu, Zhixiong Zhuang, Wen Chen*, and YM Xiao*. Heavy Metal-Induced Metallothionein Expression Is Regulated by Specific Protein Phosphatase 2A Complexes. J Biol Chem, 2014; 289(32):22413-26.
16. P Yang, JX Ma, B Zhang, HW Duan, ZN He, JL Zeng, XW Zeng, DC Li, Q Wang, YM Xiao, CX Liu, Q Xiao, LP Chen, XN Zhu, XM Xing, ZF Li, SX Zhang, ZB Zhang, L Ma, EM Wang, ZX Zhuang, YX Zheng*, Wen Chen*. CpG Site-Specific Hypermethylation of p16INK4 In Peripheral Blood Lymphocytes of PAH-Exposed Workers. Cancer Epidem Biomar, 2012; 21(1):182-90.
17. DC Li, Q Wang, CX Liu, HW Duan, XW Zeng, B Zhang, XD Li, J Zhao, SF Tang, ZF Li, XM Xing, P Yang, LP Chen, JL Zeng, XN Zhu, SX Zhang, ZB Zhang, L Ma, ZN He, EM Wang, YM Xiao, YX Zheng, W Chen*. Aberrant Expression of miR-638 Contributes to Benzo(a)pyrene–induced Human Cell Transformation. Toxicol Sci, 2012; 125(2): 382-91.
18. L-P Chen, Y-D Lai, D-C Li, X-N Zhu, P Yang, W-X Li, W Zhu, J Zhao, X-D Li, Y-M Xiao, Y Zhang, X-M Xing, Q Wang, B Zhang, Y-C Lin, J-L Zeng, S-X Zhang, C-X Liu, Z-F Li, X-W Zeng, Z-N Lin, Z-X Zhuang, and W Chen*. Alpha4 Is Highly Expressed In Carcinogen-transformed Human Cells And Primary Human Cancers. Oncogene, 2011; 30(26):2943-2953.
19. Q Wang, D-C Li, Z-F Li, C-X Liu, Y-M Xiao, B Zhang, X-D Li, J Zhao, L-P Chen, X-M Xing, S-F Tang, Y-C Lin, Y-D Lai, P Yang, J-L Zeng, Q Xiao, X-W Zeng, Z-N Lin, Z-X Zhuang and W Chen*. Upregulation of miR-27a Contributes to the Malignant Transformation of Human Bronchial Epithelial Cells Induced by SV40 Small T Antigen. Oncogene, 2011; 30(36):3875-86. 32.
20. Pang YQ, Ma RL, Li WX, Wang Q, Li DC, Xiao YM, Wei Q, Lin YC, Lai YD, Yang P, Tang S, Zhuang ZX, Zheng YX, Chen W*. Development of Human Cell Models for Assessing the Carcinogenic Potential of Chemicals. Toxicol Appl Pharm, 2008, 232:478-86.
21. Ji WD, Yang LQ, Yu L, Yuan JH, Hu DL, Zhang WJ, Yang JP, Pang YQ, Li WX, Lu JC, Fu J, Chen JK, Lin ZN, Chen W*, Zhuang ZX*. Epigenetic Silencing of O6-methylguanine-DNA Methyltransferase Gene in NiS-transformed Cells. Carcinogenesis, 2008; 29(6):1267-75.
22. Sablina AA, Chen W (co-first author), Arroyo JD, Laura Corral, Melissa Hector, Sara E. Bulmer James A. DeCaprio, and Hahn WC. The Tumor Suppressor PP2A Abeta Regulates The RalA GTPase. Cell, 2007; 129: 969-82.
23. Chen W, Possemato R, Campbell KT, Plattner CA, Pallas DC, and Hahn WC. Identification of Specific PP2A Complexes Involved in Human Cell Transformation. Cancer Cell, 2004; 5(2):127-36.
24. Chen W, Zhou YG, Nichols J, Chung KT, Hart RW, Chou MW. Effect of Dietary Restriction on Benzo[a]pyrene Metabolic Activation and Pulmonary BaP-DNA Adduct Formation in Mouse. Drug Chem Toxicol, 1996; 19(1&2):21-39.
25. Chen W, Nichols J, Zhou YG, Chung KT, Hart RW, Chou MW. Effect of Dietary Restriction on Glutathione S-transferase Activity Specific Toward Aflatoxin B1-8,9-epoxide. Toxicol Lett, 1995; 78:235-43.
【研究生培养情况】
博士生毕业24名
硕士生毕业48名
【招生专业】
卫生毒理学
劳动卫生与职业病
【获奖情况】
全国优秀科技工作者 2014年
中国毒理学杰出贡献奖 2017年
