【学术简历】
2002/09-2005/07 军事医学科学院 博士学位
1999/09-2002/07 解放军军需大学 硕士学位
1995/09-1999/06 解放军农牧大学 学士学位
先后任军事医学科学院疾病预防控制所助理研究员（2005-2007）、副研究员（2007-2014）及研究员（2014-2016）、解放军公共卫生应急处置大队侦检队队长（2010-2016）、军事医学科学院疾病预防控制所传染病控制中心副主任（2010-2016）、天康生物股份有限公司研发中心创新团队首席专家（2017-2020）、辽宁省人兽共患病研究重点实验室副主任（2017-），2020年至今于bbin平台-bbin官网-bbin电子
流行病与卫生统计学系任教，特聘副教授，博士生导师。
入选省级高层次人才计划，长期以来主要从事疾病预防控制工作及相关研究，先后主持国家重点研发计划项目课题、国家863专题、国家自然科学基金重点项目、传染病重大专项子任务课题等科研项目10余项，先后发表SCI论文90余篇，授权专利10项，获批新兽药证书1项，诊断产品CE证书10项。
【招生方向】
流行病与卫生统计学
【社会兼职】
中国医学会地方病学会理事
中国微生物学会分析微生物委员
中国地方病防治杂志编委
【主要承担或参与的课题（5-6项代表性课题）】
1.2020.01-2022.12，布鲁氏菌致反刍动物流产的风险因素与作用机制研究，国家自然自然科学基金国际（地区）合作与交流项目，175万（主持人）
2.2019.01-2022.12，反刍动物布鲁氏菌病免疫预防的基础研究，国家自然科学基金重点项目, 246万（主持人）
3.2017.07-2020.12，病原菌逃逸宿主免疫与胞内存活的分子机制，国家重点研发计划项目,485万（主持人）
4.2019.07-2022.12，人畜间布病综合防控技术集成与示范，内蒙古自治区重大科技专项，1430万（主持人）
5.2016.01-2018.12，动物源性微生物变异机制与播散规律，国家重点研发计划项目，298万（子课题负责人）
【近期发表的主要文章，*通信作者】
2020年
1. Niu Y, Yang L, Gao T, Dong C, Zhang B, Yin P, Hopp AK, Li D, Gan R, Wang H, Liu X, Cao X, Xie Y, Meng X, Deng H, Zhang X, Ren J, Hottiger MO, Chen Z*（并列通讯）, etc. A Type I-F Anti-CRISPR Protein Inhibits the CRISPR-Cas Surveillance Complex by ADP-Ribosylation. Mol Cell. 2020 Oct 6:S1097-2765(20)30645-6. doi: 10.1016/j.molcel.2020.09.015. Online ahead of print.
2. Zhang Q, Li C, Wang Y, Li Y, Han X, Zhang H, Wang D, Liao Y, Chen Z*. Temporal and spatial distribution trends of human brucellosis in Liaoning Province, China.Transbound Emerg Dis. 2020, doi: 10.1111/tbed.13739.
3. Wang J, Li Z, Cheng X, Hu H, Liao C, Li P, Lu J, Chen Z*. Epidemiologic Characteristics, Transmission Chain, and Risk Factors of Severe Infection of COVID-19 in Tianjin, a Representative Municipality City of China. Front Public Health. 2020 May 20;8:198.
4. Liu J, Lu G, Cui Y, Wei S, An T, Shen G, Chen Z*.An insight into the transmission role of insect vectors based on the examination of gene characteristics of African swine fever virus originated from non-blood sucking flies in pig farm environments. BMC Vet Res. 2020 Jul 2;16(1):227.
5. Tao D, Sun D, Liu Y, Wei S, Yang Z, An T, Shan F, Chen Z*, Liu J. One year of African swine fever outbreak in China. Acta Trop. 2020 Jun 26;211:105602.
6. Baoshan L, Yinbo Y, Jingbo Z, Yi Z, Jianghua Y, Dawei C, Chi M, Donghai Y, Bohan Y, Rongnian Z, Sheng F, Jun Z, Han X, Chen Z*. Combined nucleic acid assays for diagnosis of A19 vaccine-caused human brucellosis. Transbound Emerg Dis. 2020 Jun 16. doi: 10.1111/tbed.13685.
7. Chen ZL, Zhang Q, Lu Y, Guo ZM, Zhang X, Zhang WJ, Guo C, Liao CH, Li QL, Han XH, Lu JH. Distribution of the COVID-19 epidemic and correlation with population emigration from Wuhan, China. Chin Med J (Engl). 2020 May 5;133(9):1044-1050.
8. Chen ZL, Zhang WJ, Lu Y, Guo C, Guo ZM, Liao CH, Zhang X, Zhang Y, Han XH, Li QL, Lu JH. From severe acute respiratory syndrome-associated coronavirus to 2019 novel coronavirus outbreak: similarities in the early epidemics and prediction of future trends.Chin Med J (Engl). 2020 May 5;133(9):1112-1114.
9. Liu J, Liu B, Shan B, Wei S, An T, Shen G, Chen Z*. Prevalence of African Swine Fever in China, 2018-2019. J Med Virol. 2020 Aug;92(8):1023-1034.
2019年
10. Zhang TT, Liu MZ, Yin RH, Yao LQ, Liu BS, Chen ZL*. Rapid and simple detection of Glaesserella parasuis in synovial fluid by recombinase polymerase amplification and lateral flow strip. BMC Vet Res. 2019 Aug 14;15(1):294.
11. Xu H, Zhang Q, Guan H, Zhong Y, Jiang F, Chen Z*, Han X. High Incidence of a Novel Rickettsia Genotype in Parasitic Haemaphysalis longicornis from China-North Korea Border. Sci Rep. 2019 Mar 29;9(1):5373. doi: 10.1038/s41598-019-41879-7.
12. Wang Y, Ke Y, Duan C, Ma X, Hao Q, Song L, Guo X, Sun T, Zhang W, Zhang J, Zhao Y, Zhong Z, Yang X, Chen Z*. A small non-coding RNA facilitates Brucella melitensis intracellular survival by regulating the expression of virulence factor. Int J Med Microbiol. 2019 May - Jun;309(3-4):225-231.
13. Liu MZ, Han XH, Yao LQ, Zhang WK, Liu BS, Chen ZL*. Development and application of a simple recombinase polymerase amplification assay for rapid point-of-care detection of feline herpesvirus type 1. Arch Virol. 2019 Jan;164(1):195-200.
2018年
14. S Ding, X Han, J Li, W Gao, Z Chen*, Y Feng. Discovery of multi-drug resistant, MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China. Science Bulletin. 2018, 63:16, 1059-1066.
2017年
15. Yang M, Ke Y, Zhang W, Liu C, Yang R, Chen Z*. RT-PCR using glycoprotein target is more sensitive for the detection of Ebola virus in clinical samples. Diagn Microbiol Infect Dis. 2017 Mar;87(3):235-237.
16. Liu SW, Xu XY, Xu J, Yuan JY, Wu WK, Zhang N, Chen ZL*. Multi-drug resistant uropathogenic Escherichia coli and its treatment by Chinese medicine. Chin J Integr Med. 2016 Dec 27. doi: 10.1007/s11655-016-2738-0.
2016年
17. Li W, Ke Y, Wang Y, Yang M, Gao J, Zhan S, Xinying D, Huang L, Li W, Chen Z*, Li J. Brucella TIR-like protein TcpB/Btp1 specifically targets the host adaptor protein MAL/TIRAP to promote infection.Biochem Biophys Res Commun. 2016 Jun 13. doi: 10.1016/j.bbrc.2016.06.064.
18. Ke Y, Li W, Wang Y, Yang M, Guo J, Zhan S, Du X, Wang Z, Yang M, Li J, Li W, Chen Z*. Inhibition of TLR4 signaling by Brucella TIR-containing protein TcpB-derived decoy peptides.Int J Med Microbiol. 2016 Sep;306(6):391-400.
19. Yang M, Ke Y, Wang X, Ren H, Liu W, Lu H, Zhang W, Liu S, Chang G, Tian S, Wang L, Huang L, Liu C, Yang R, Chen Z*.Development and Evaluation of a Rapid and Sensitive EBOV-RPA Test for Rapid Diagnosis of Ebola Virus Disease. Sci Rep. 2016 Jun 1;6:26943.
20. Zhong Z, Xu X, Li X, Liu S, Lei S, Yang M, Yu J, Yuan J, Ke Y, Du X, Wang Z, Ren Z, Peng G, Wang Y, Chen Z*.Large-scale identification of small noncoding RNA with strand-specific deep sequencing and characterization of a novel virulence-related sRNA in Brucella melitensis. Sci Rep. 2016 Apr 26;6:25123.
21. Wang X, Li X, Liu S, Ren H, Yang M, Ke Y, Huang L, Liu C, Liu B, Chen Z*: Ultrasensitive Detection of Bacteria by Targeting Abundant Transcripts. Sci Rep 2016, 6:20393.
22. Ren H, Yang M, Zhang G, Liu S, Wang X, Ke Y, Du X, Wang Z, Huang L, Liu C, Chen Z*: Development of a rapid recombinase polymerase amplification assay for detection of Brucella in blood samples. Mol Cell Probes. 2016 Apr;30(2):122-4.
23. Chen Z, Liang H, Chen X, Ke Y, Zhou Z, Yang M, Zen K, Yang R, Liu C, Zhang C-Y: An Ebola virus-encoded microRNA-like fragment serves as a biomarker for early diagnosis of Ebola virus disease. Cell Res. 2016 Mar;26(3):380-3.
24. Lei S, Zhong Z, Ke Y, Yang M, Xu X, Ren H, An C, Yuan J, Yu J, Xu J, Qiu Y, Shi Y, Wang Y, Peng G, Chen Z*.Deletion of the Small RNA Chaperone Protein Hfq down Regulates Genes Related to Virulence and Confers Protection against Wild-Type Brucella Challenge in Mice. Front Microbiol. 2016 Jan 20;6:1570.
2015年
25. Wang Y, Ke Y, Xu J, Wang L, Wang T, Liang H, Zhang W, Gong C, Yuan J, Zhuang Y, An C, Lei S, Du X, Wang Z, Li W, Yuan X, Huang L, Yang X, Chen Z*: Identification of a Novel Small Non-Coding RNA Modulating the Intracellular Survival of Brucella melitensis. Front Microbiol 2015, 6:164.
26. Wang X, An C, Yang M, Li X, Ke Y, Lei S, Xu X, Yu J, Ren H, Du X, Wang Z, Qiu Y, Liu B, Chen Z*: Immunization with individual proteins of the Lrp/AsnC family induces protection against Brucella melitensis 16M challenges in mice. Front Microbiol 2015, 6:1193.
27. Ke Y, Wang Y, Li W, Chen Z*: Type IV secretion system of Brucella spp. and its effectors. Front Cell Infect Microbiol 2015, 5:72.
28. Chen Z, Chang G, Zhang W, Chen Y, Wang X, Yang R, Liu C: Mobile laboratory in Sierra Leone during outbreak of Ebola: practices and implications. Sci China Life Sci 2015, 58(9):918-921.
2013年
29. Zhen Q, Lu Y, Yuan X, Qiu Y, Xu J, Li W, Ke Y, Yu Y, Huang L, Wang Y, Chen Z*: Asymptomatic brucellosis infection in humans: implications for diagnosis and prevention. Clin Microbiol Infect 2013, 19(9):E395-397.
30. Zhang N, Huang L, Liu S, Wang Y, Luo Y, Jin X, Guo J, Ke Y, Chen J, Yuan X, Chen Z*: Traditional chinese medicine: an alternative treatment option for refractory recurrent urinary tract infections. Clin Infect Dis 2013, 56(9):1355.
31. Xu J, Qiu Y, Cui M, Ke Y, Zhen Q, Yuan X, Yu Y, Du X, Yuan J, Song H, Wang Z, Gao G, Yu S, Wang Y, Huang L, Chen Z*: Sustained and differential antibody responses to virulence proteins of Brucella melitensis during acute and chronic infections in human brucellosis. Eur J Clin Microbiol Infect Dis 2013, 32(3):437-447.
32. Wang Y, Zhang W, Ke Y, Zhen Q, Yuan X, Zou W, Li S, Sun Y, Wang Z, Wang D, Cui B, Song H, Huang L, Chen Z*: Human brucellosis, a heterogeneously distributed, delayed, and misdiagnosed disease in china. Clin Infect Dis 2013, 56(5):750-751.
33. Liu S, Zhang N, Chen Z*: Recurrent urinary tract infections caused by multidrug-resistant uropathogenic Escherichia coli: implications for diagnosis and treatment. Eur Urol 2013, 63(2):410-411.
34. Ke Y, Zhen Q, Wang Y, Yuan X, Li W, Lu Y, Qiu Y, Yu Y, Huang L, Chen Z*: Window of treatment initiation for human brucellosis, implications for treatment efficacy, and prevention of chronic infection. Clin Infect Dis 2013, 56(9):1350-1352.
35. Ke Y, Wang Y, Zhang W, Huang L, Chen Z*: Deaths associated with avian influenza A(H7N9) virus in China. Ann Intern Med 2013, 159(2):159-160.
36. Ke Y, Wang Y, Wang Z, Du X, Huang L, Chen Z*: Sensitive and rapid detection of blandm-1 in Clinical Samples by Isothermal Cross-Priming Amplification. J Microbiol Methods 2013.
37. Ke Y, Wang Y, Liu S, Guo J, Zhang W, Yuan X, Zhang N, Wang Z, Song H, Huang L, Chen Z*: High severity and fatality of human infections with avian influenza A(H7N9) infection in China. Clin Infect Dis 2013, 57(10):1506-1507.
38. Feng Y, Xu J, Zhang H, Chen Z*#, Srinivas S*#: Brucella BioR Regulator Defines a Complex Regulatory Mechanism for Bacterial Biotin Metabolism. J Bacteriol 2013, 195(15):3451-3467.
39. Cui M, Wang T, Xu J, Ke Y, Du X, Yuan X, Wang Z, Gong C, Zhuang Y, Lei S, Su X, Wang X, Huang L, Zhong Z, Peng G, Yuan J, Chen Z*#, Wang Y*#: Impact of Hfq on Global Gene Expression and Intracellular Survival in Brucella melitensis. PLoS One 2013, 8(8):e71933.
40. Chen Z, Zhang W, Ke Y, Wang Y, Tian B, Wang D, Cui B, Zou W, Li S, Huang L, Song H: High-risk regions of human brucellosis in china: implications for prevention and early diagnosis of travel-related infections. Clin Infect Dis 2013, 57(2):330-332.
41. Chen Z, Wang Y, Wang Z, Ke Y, Zhen Q, Yuan X, Zhang W, Lu Y, Yu Y, Song H, Huang L: Improvement and advancement of early diagnosis of human brucellosis in window period. Clin Infect Dis 2013, 57(2):322-323.
42. Chen Y, Ke Y, Wang Y, Yuan X, Zhou X, Jiang H, Wang Z, Zhen Q, Yu Y, Huang L, Cui B, Chen Z*: Changes of predominant species/biovars and sequence types of Brucella isolates, Inner Mongolia, China. BMC Infect Dis 2013, 13:514.
2012年
43. Zhong Z, Wang Y, Xu J, Chen Y, Ke Y, Zhou X, Yuan X, Zhou D, Yang Y, Yang R, Peng G, Jiang H, Yuan J, Song H, Cui B, Huang L, Chen Z*: Parallel gene loss and acquisition among strains of different Brucella species and biovars. J Microbiol 2012, 50(4):567-574.
44. Zhong Z, Wang L, Chen Y, Wang Z, Wang Y, Cui M, Li T, Ke Y, Yuan X, Wang D, Chen Z*#, Peng G*#: Complete genome sequence of Brucella abortus strain BCB034, a strain of biovar 2 isolated from human. J Bacteriol 2012, 194(24):6943.
45. Wang Y, Ke Y, Zhen Q, Yuan X, Xu J, Qiu Y, Wang Z, Li T, Wang D, Huang L, Chen Z*: Complete genome sequence of Brucella canis BCB018, a strain isolated from a human patient. J Bacteriol 2012, 194(23):6697-6698.
46. Wang Y, Ke Y, Wang Z, Yuan X, Qiu Y, Zhen Q, Xu J, Li T, Wang D, Huang L, Chen Z*: Genome sequences of three live attenuated vaccine strains of Brucella species and implications for pathogenesis and differential diagnosis. J Bacteriol 2012, 194(21):6012-6013.
47. Wang Y, Ke Y, Gao G, Zhen Q, Yuan X, Wang Z, Xu J, Li T, Wang D, Huang L, Xu X, Chen Z*: Complete genome sequence of Brucella abortus 134, a biovar 1 strain isolated from human. J Bacteriol 2012, 194(23):6658.
48. Song S, Yuan X, Liu S, Zhang N, Wang Y, Ke Y, Xu J, Huang L, Chen Z*#, Li Y*#: Genome sequence of Stenotrophomonas maltophilia S028, an isolate harboring the AmpR-L2 resistance module. J Bacteriol 2012, 194(23):6696.
49. Liu S, Wang Y, Xu J, Li Y, Guo J, Ke Y, Yuan X, Wang L, Du X, Wang Z, Huang L, Zhang N, Chen Z*: Genome sequence of an OXA23-producing, carbapenem-resistant Acinetobacter baumannii strain of sequence type ST75. J Bacteriol 2012, 194(21):6000-6001.
50. Li X, Xu J, Xie Y, Qiu Y, Fu S, Yuan X, Ke Y, Yu S, Du X, Cui M, Chen Y, Wang T, Wang Z, Yu Y, Huang K, Huang L, Peng G, Chen Z*#, Wang Y*#: Vaccination with recombinant flagellar proteins FlgJ and FliN induce protection against Brucella abortus 544 infection in BALB/c mice. Vet Microbiol 2012, 161(1-2):137-144.
51. Li T, Yuan X, Ding J, Zhen Q, Ke Y, Wang Y, Huang L, Mao K, Chen Z*#, Wang D*#: Genome sequence of Brucella melitensis strain 128, an isolate of biovar 3 of sequence type 8. J Bacteriol 2012, 194(24):6960.
52. Ke Y, Zhen Q, Li T, Wang Y, Yuan X, Xu J, Huang L, Wang D, Song H, Chen Z*: Complete genome sequence of Brucella melitensis 133, an isolate of biovar 1 of sequence type 32. J Bacteriol 2012, 194(24):6932.
53. Ke Y, Yuan X, Zhen Q, Wang Y, Li T, Sun Y, Song H, Huang L, Wang D, Cui B, Mao K, Chen Z*: Genome sequence of Brucella melitensis S66, an isolate of sequence type 8, prevalent in China. J Bacteriol 2012, 194(19):5451.
54. Ke Y, Yuan X, Wang Y, Bai Y, Xu J, Song H, Huang L, Chen Z*: Genome sequences of Brucella melitensis 16M and its two derivatives 16M1w and 16M13w, which evolved in vivo. J Bacteriol 2012, 194(19):5489.
55. Ke Y, Wang Y, Yuan X, Zhong Z, Qu Q, Zhou D, Zeng X, Xu J, Wang Z, Du X, Wang T, Yang R, Zhen Q, Yu Y, Huang L, Chen Z*: Altered Transcriptome of the B. melitensis Vaccine Candidate 16M_vjbR, Implications for Development of Genetically Marked Live Vaccine. Indian Journal of Microbiology 2012, 52(4):575-580.
56. Ke Y, Wang Y, Yuan X, Xu J, Zhen Q, Wang Z, Li T, Wang D, Huang L, Song H, Chen Z*: Complete genome sequence of Brucella suis field strain BCB025 of sequence type ST22. J Bacteriol 2012, 194(24):6959.
57. Gao G, Li J, Li T, Zhang Z, Wang L, Yuan X, Wang Y, Xu J, Ke Y, Huang L, Wang D, Chen Z*#, Xu X*#: Complete genome sequence of Brucella canis strain 118, a strain isolated from canine. J Bacteriol 2012, 194(23):6680.
2011年
58. Fu S, Xu J, Li X, Xie Y, Qiu Y, Du X, Yu S, Bai Y, Chen Y, Wang T, Wang Z, Yu Y, Peng G, Huang K, Huang L, Wang Y, Chen Z*: Immunization of mice with recombinant protein CobB or AsnC confers protection against Brucella abortus infection. PLoS One 2012, 7(2):e29552.
59. Chen Y, Zhen Q, Wang Y, Xu J, Sun Y, Li T, Gao L, Guo F, Wang D, Yuan X, Yuan J, Huang L, Chen Z*#, Yu Y*#.Development of an extended multilocus sequence typing for genotyping of Brucella isolates.J Microbiol Methods. 2011 Aug;86(2):252-4.
60. Wang Y, Bai Y, Qu Q, Xu J, Chen Y, Zhong Z, Qiu Y, Wang T, Du X, Wang Z, Yu S, Fu S, Yuan J, Zhen Q, Yu Y, Chen Z*#, Huang L*#.The 16MΔvjbR as an ideal live attenuated vaccine candidate for differentiation between Brucella vaccination and infection. Vet Microbiol. 2011 Aug 5;151(3-4):354-62.
61. Chen Z, Qlu S, Wang Y, Wang Y, Liu S, Wang Z, Du X, Wang L, Guo J, Wang Z, Liu N, Yuan J, Song H, Huang L.Coexistence of blaNDM-1 with the prevalent blaOXA23 and blaIMP in pan-drug resistant Acinetobacter baumannii isolates in China.Clin Infect Dis. 2011 Mar 1;52(5):692-3.
【所获荣誉】
获授权专利5项
软件著作权4项
新药证书1项
诊断试剂CE证书3项
获吉林省科技进步二等奖1项（第二）
中华预防医学会科技进步二等奖1项（第五）
解放军个人二等功1次、三等功1次
【联系方式】
地址： 广东省广州市越秀区中山二路74号bbin平台-bbin官网-bbin电子
电话：020-87335382
E-mail：[email protected]
